Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 236-818-1 | CAS number: 13497-18-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 Oct - 29 Nov 2004
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: ISO Standard 14669: Water Quality - Determination of Acute Lethal Toxicity to Marine Copepods (Copepoda, Crustacea), 1999.
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Control and all concentrations
- Sampling method: Duplicate samples of at least 50 mL were taken
- Sample storage conditions before analysis: Stored at -18 to -25 °C prior to analysis - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A 200 mg/L stock solution was prepared in synthetic seawater by stirring for 1 hour. The stock solution was used directly as the test medium. It is likely that the nominal concentration exceeded the solubility of the test substance in the test medium. - Test organisms (species):
- other: Acartia tonsa (Dana)
- Details on test organisms:
- TEST ORGANISM
- Source: From laboratory stock culture at ECT Oekotoxicologie GmbH. The stock culture was originally supplied by the Technical University of Denmark, Lyngby, Denmark.
- Age at study initiation (mean and range, SD): 14-21 days
- Feeding during test: none
ACCLIMATION
- Type and amount of food: algae (Rhodomonas salina)
- Feeding frequency: daily
- Acclimation period in test medium: 9 days - Test type:
- static
- Water media type:
- saltwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- not reported
- Test temperature:
- 19.7-21.1 °C
- pH:
- 7.6-8.7
- Dissolved oxygen:
- 7.8-8.5 mg/L
- Salinity:
- 30.3 ppt
- Nominal and measured concentrations:
- Nominal concentrations: 0 (Control) and 200 mg/L
Measured concentrations were 79.3% of nominal at the start of the test and 72.5% of nominal at the end of the test
Measured initial: 0 and 151.9 mg/L
The measured concentration at the end of the test was 91.4% of the measured concentration at the start of the test. - Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers
- Type: covered by glass lids
- Material, size, headspace, fill volume: glass, 100 mL and containing between 50 and 80 mL of test medium
- Aeration: none
- Renewal rate of test solution (frequency/flow rate): none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 6
- No. of vessels per control (replicates): 6
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Synthetic seawater prepared in accordance with Kusk and Wollenberger (1999). Fully defined saltwater medium for cultivation of and toxicity testing with marine copepod Acartia tonsa. Env Toxicol Chem 18:1564-1567
- Intervals of water quality measurement: Daily
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h light, 8 h dark
- Light intensity: 539 Lux
EFFECT PARAMETERS MEASURED: Mortality after 24 and 48 hours
TEST CONCENTRATIONS
- Spacing factor for test concentrations: Limit test - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 151.9 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control: 0%
- Results with reference substance (positive control):
- - Results with reference substance valid?: yes
- 48-h LC50: 0.749 mg/L (95% CI: 0.634-0.884 mg/L) - Reported statistics and error estimates:
- No toxic effects were observed in the test and therefore statistical analysis of the results was not required.
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-h EC50 value of > 151.9 mg/L and a NOEC of ≥ 151.9 mg/L (both meas. init.) have been determined in the study (ISO 14669) testing the effects of 3-(triethoxysilyl)-N-[3-(triethoxysilyl)propyl]-1-propanamine towards Acartia tonsa.
Reference
Table 1. Results of analysis of test media
Nominal test substance concentration (mg/L) |
Mean measured concentration in fresh test medium at start of test (mg/L) |
Mean measured concentration in old test medium after 48 hours (mg/L) |
Mean measured concentration at start of test as percentage of nominal |
Mean measured concentration after 48 hours as percentage of nominal |
0 (Control) |
0.8 |
1.1 |
- |
- |
192 |
152 |
139 |
79 |
73 |
No toxics effects were observed at the single test concentration of 151.9 mg/L (meas. init.) resulting into a NOEC (48 h) of >= 151.9 mg/L (meas. init.)
Description of key information
EC50 (48 h) > 151.9 mg/L (meas. init., Acartia tonsa, ISO 14669)
Key value for chemical safety assessment
Marine water invertebrates
Marine water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 151.9 mg/L
Additional information
Experimental data are available testing the acute toxicity of 3-(triethoxysilyl)-N-[3-(triethoxysilyl)propyl]-1-propanamine (CAS No. 13497-18-2) towards aquatic invertebrates. The study was performed according to the ISO guideline 14669 and GLP standards (2004). The salt water organism Acartia tonsa was used for testing and was exposed for 48 h in a static testing regime to one single nominal test item concentration of 200 mg/L and a control. The test item was monitored via measurement of DOC at the beginning and at the end of the experiment. The recoveries of the test substance were between 72.5 and 79.3%. No toxic effects were recorded up to the highest tested concentration and thus the study resulted into a 48-h EC50 value of > 151.9 mg/L (meas. initial).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.