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EC number: 202-700-3 | CAS number: 98-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The experimental work associated with this study was carried out between 11 November 2016 and 22 March 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- gas saturation method
- Specific details on test material used for the study:
- Test substances: (2S)-5-oxopyrrolidine-2-carboxylic acid Technical Materials
Acid Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Acid Source)
Salt Source: (2S)-5-oxopyrrolidine-2-carboxylic acid (Potassium Salt)
Received on: 8th November 2016
DNAL Sample Numbers: DNA3730/1-2
Reference Standard: (S)-(-)-2-Pyrrolidinone-5-carboxylic acid reference standard
Received on: 6th January 2017 - Key result
- Test no.:
- #1
- Temp.:
- ca. 25 °C
- Vapour pressure:
- < 2 other: mPa
- Remarks on result:
- other: using 360L of gas flow through the column
- Key result
- Test no.:
- #2
- Temp.:
- ca. 25 °C
- Vapour pressure:
- < 8 other: mPa
- Remarks on result:
- other: using 72L of gas flow through the column.
- Conclusions:
- According to the results obtained in this test, the mean Vapour Pressure of (2S)-5-oxopyrrolidine-2-carboxylic acid is <2.0mPa at 25°C using 360L of gas flow through the column.
According to the results obtained in this test, the mean Vapour Pressure of (2S)-5-oxopyrrolidine-2-carboxylic acid is <8.0mPa at 25°C using 72L of gas flow through the column.
Reference
Vapour Pressure (72L of gas through the column) Results Reference Standard
Description | Data File | Retention time (mins) | Unit Area | Response Factor | Concentration (mg/mL) | Weight in (g) on sorbant tube | Vapour pressure (Pa) | Vapour pressure (mPa) |
0.05mg/mL L-PCA | L1603S9 | 5.18 | 414.04 | 0.000121 | ||||
L-PCA Ref Standard/A VP Front 1 Day | LL603V1 | ND | ND | <0.002 | 0.00003 | <0.008 | <0.8 | |
L-PCA Ref Standard/B VP Front 1 Day | LL603V2 | ND | ND | <0.002 | 0.00003 | <0.008 | <8.0 | |
0.05mg/mL L-PCA | L1603S10 | 5.19 | 411.35 | 0.000122 | Mean | <0.008 | <8.0 | |
L-PCA Ref Standard/A VP Back 1 Day | LL603V3 | ND | ND | <0.002 | 0.00003 | <0.008 | <8.0 | |
L-PCA Ref Standard/B VP Back 1 Day | LL603V4 | ND | ND | <0.002 | 0.00003 | <0.008 | <8.0 | |
0.05mg/mL L-PCA | L1603S11 | 5.20 | 409.02 | Mean: | <0.008 | <8.0 |
Vapour pressure (360L o f gas through the column) Results Reference Standard
Description | Data File | Retention time (mins) | Unit Area | Response Factor | Concentration (mg/mL) | Weight in (g) on sorbant tube | Vapour pressure (Pa) | Vapour pressure (mPa) |
0.05mg/mL L-PCA | L1603S11 | 5.20 | 409.02 | 0.000121 | ||||
L-PCA Ref Standard/A VP Front 5 Day | LL603V5 | ND | ND | <0.002 | 0.00003 | <0.002 | <2.0 | |
L-PCA Ref Standard/B VP Front 5 Day | LL603V6 | ND | ND | <0.002 | 0.00003 | <0.002 | <2.0 | |
0.05mg/mL L-PCA | L1603S12 | 5.21 | 417.38 | 0.000118 | Mean | <0.002 | <2.0 | |
L-PCA Ref Standard/A VP Back 5 Day | LL603V7 | ND | ND | <0.002 | 0.00003 | <0.002 | <2.0 | |
L-PCA Ref Standard/B VP Back 5 Day | LL603V8 | ND | ND | <0.002 | 0.00003 | <0.002 | <2.0 | |
0.05mg/mL L-PCA | L1603S13 | 5.21 | 428.79 | Mean: | <0.002 | <2.0 |
Where:
Response Factor= 0.05/mean standard bracket area
Concentration (mg/mL) =Less than Lowest standard concentration (LOQ)
Molecular Weight= 129.12
Temperature (K) = 298
Gas Constant= 8.314
Volume (m3) =((Time (in hours) x 60 x 50)/1000)/1000
Grams on tube = Concentration x 15/ 1000
Vapour Pressure Pa= (grams on tube /volume) x ((8.314 x 298)/129.12)
Vapour Pressure mPa = Vapour Pressure Pa x 1000
No significant deviation was recorded in this part of the study.
Description of key information
The mean Vapour Pressure of (2S)-5-oxopyrrolidine-2-carboxylic acid is <2.0mPa at 25°C using 360L of gas flow through the column and <8.0mPa at 25°C using 72L of gas flow through the column.
Key value for chemical safety assessment
- Vapour pressure:
- 0.002 Pa
- at the temperature of:
- 25 °C
Additional information
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