Dodecyl laurate

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Remarks:

Summary of available data used for the endpoint assessment of the target substance.

Adequacy of study:

key study

Justification for type of information:

Refer to the analogue approach justification provided in IUCLID section 13.

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Duration:

21 d

Dose descriptor:

NOELR

Effect conc.:

>= 10 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

reproduction

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 95912-86-0, BASF, 2013, D. magna, 21 d

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

>= 1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Remarks:

(WAF)

Basis for effect:

reproduction

Remarks on result:

other:

Remarks:

Source: RA-A, CAS 135800-37-2, BASF, 1998, D. magna, 21 d

Conclusions:

The key values retained for the long-term toxicity of the target substance to aquatic invertebrates are a NOELR (21 d) of ≥ 10 mg/L and a NOEC (21 d) of ≥ 1 mg/L (WAF) based on the available experimental studies for two structurally and chemically closely related source substances (nominal, OECD 211, D. magna); read-across

Description of key information

No effects up to the limit of water solubility (OECD 211, D. magna); read-across

Additional information

There is no study available, in which the long-term toxicity of lauryl laurate (CAS 13945-76-1) to aquatic invertebrates was investigated. Therefore, read-across to the two structurally related source substances fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0) and fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2)was conductedin accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid and alcohol components and are therefore considered suitable representatives for the assessment of the long-term toxicity of the target substance to aquatic invertebrates. A detailed justification of the analogue approach is provided in IUCLID section 13.

Both the available studies were conducted according to GLP.

In the study with the source substance fatty acids, C8-10, C12-18-alkyl esters (CAS 95912-86-0), a semi-static limit test was performed according to OECD 211, in which Daphnia magna was exposed to a water accommodated fraction with a nominal loading rate of 10 mg/L for 21 d. A chemical analysis of the test item concentrations was not possible because no suitable analytical method was found to detect the poorly soluble substance. After 21 d, no effects on reproduction of D. magna were observed up to the limit of water solubility (< 0.05 mg/L), resulting in a NOELR (21 d) ≥ 10 mg/L. Based on this result it can be concluded that fatty acids, C8-10, C12-18-alkyl esters does not cause chronic toxicological effects on aquatic invertebrates up to the limit of water solubility.

In the study with the source substance fatty acids, C8-16, 2-ethylhexyl esters (CAS 135800-37-2), a semi-static test was performed according to OECD 202, part II (1984), in which D. magna was exposed to filtered test solutions with nominal test item loading rates of 1 and 100 mg/L for 21 d.

After 21 d, no effects on mortality and reproduction was observed in the filtered solution of 1 mg/L. However, a significant reduction of reproduction was recorded in the filtered solution of 100 mg/L. The authors supposed that the observed effects in the 100 mg/L filtered test solution were either due to a better water soluble by-compound (e.g. a short chain fatty acid ester) or, less likely, due to a toxic impurity. Therefore, a NOEC for reproduction (21 d) of ≥ 1 mg/L (nominal) was reported.

Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar ecotoxicological profile as the selected source substances. Therefore, it can be concluded that the target substance lauryl laurate (CAS 13945-76-1) does not cause long-term toxicological effects on aquatic invertebrates up to the limit of water solubility.