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EC number: 219-834-3 | CAS number: 2549-51-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- other: Expert assessment
- Adequacy of study:
- weight of evidence
- Study period:
- 09 May 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert assessment based on literature data on the degradation products of VCA
- Justification for type of information:
- An experimental study to determine the toxicity of VCA to fish was not considered necessary, nor scientifically justified, since the registered substance is expected to undergo rapid abiotic transformation upon contact with water. Therefore the degradation products of VCA were assessed instead in order to calculate an EC50 value for VCA.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An expert assessment was performed based on literature data on the degradation products of VCA.
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- ca. 84.084 mg/L
- Remarks on result:
- other: Expert assessment based on existing literature data on the degradation products
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- It is not scientifically necessary to perform a study on the toxicity of VCA to fish, since it degrades rapidly in water to form Chloroacetic acid and Acetaldehyde. The aquatic toxicity of VCA is expected to be driven by the toxicity of these degradation products. The 96 hour LC50 for VCA was calculated to be 84.084 mg/L which is the lowest calculated LC50 value based on literature data across both degradation products.
- Executive summary:
VCA has been found to hydrolyse rapidly (t1/2 12 hrs) upon contact with water to give two main degradation products: Chloroacetic acid (CAS 79-11-8 / EC 201-178-4) and Acetaldehyde (CAS 75-07- 0 / EC 200-836-8). Subsequently, the toxicity of VCA to fish was determined by means of expert assessment, based on the ecotoxicity of its degradation products, for which substantial literature data is already available. A literature search was conducted to obtain a value for the toxicity of Chloroacetic acid and Acetaldehyde to fish. Considering the uses of VCA, it is the toxicity to freshwater species that was considered. The lowest calculated LC50 value was taken from across both degradation products, in order to take the most conservative approach. The degradation product with the lowest EC50 for fish was found to be acetaldehyde with a 96-hour LC50 of 30.8 mg/L obtained on Pimephales promelas. For the purpose of the assessment it was assumed that VCA hydrolyses entirely into the two degradation products. To produce this amount of acetaldehyde, 84.084 mg/L VCA must be hydrolysed. Therefore, it can be concluded that the 96 hour LC50 for the toxicity of VCA to fish is 84.084 mg/L.
Reference
Description of key information
It is not scientifically necessary to perform a study on the toxicity of VCA to fish, since it degrades rapidly in water to form Chloroacetic acid and Acetaldehyde. The aquatic toxicity of VCA is expected to be driven by the toxicity of these degradation products. The 96 hour LC50 for VCA was calculated to be 84.084 mg/L which is the lowest calculated LC50 value based on literature data across both degradation products.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 84.084 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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