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Diss Factsheets
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EC number: 801-282-5 | CAS number: 1034343-98-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Oct 2019 - 20 Feb 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- Version not mentioned
- Deviations:
- yes
- Remarks:
- temperature and pH measurement is missing flow rate lower than in OECD 105
- Principles of method if other than guideline:
- - Principle of test:
The test item was evaluated using the equilibrated-column technique for water saturation and then total carbon analysis was performed to determine the carbon concentration followed prolonged periods of continuous column perfusion. The OECD 105 “column elution method” was developed to establish equilibrium conditions for determining the test substance solubility in water within a 7 to 11 day total equilibration time.
- Parameters analysed / observed: Total carbon analysis was conducted to determine the percent carbon of the test substance and the measured solubility of the test substance in water. - GLP compliance:
- yes
- Remarks:
- no certificate included in report
- Type of method:
- column elution method
- Water solubility:
- < 3 mg/L
- Conc. based on:
- other: Net Total Carbon
- Loading of aqueous phase:
- 500 other: mg
- Incubation duration:
- >= 5 - <= 11 d
- Remarks on result:
- other: not determinable due to low solubility of test substance (< LOD)
- Remarks:
- Temperature and pH not specified
- Details on results:
- The experimentally determined carbon content of the test substance was 8.5 ppm +/- 4.1 ppm; Blank Sample TC was 9.3 ppm, net total carbon was below the LOD of 3 ppm.
- Conclusions:
- The water solubility of the test item was determined to be <3 mg/L based on net total carbon according to OECD 105 using the column equilibration method (modified).
- Executive summary:
Water solubility was determined for the test item based on a saturation equilibrium using the column elution method. Total carbon analysis was performed following 5 to 11 days of equilibration. Total carbon measured from the equilibrated test item was 8.5 (+/- 4.1) ppm and total carbon measured from a blank DDI control was 9.8 ppm. From this assessment, no net carbon was recovered above the 3 ppm LOD for the test system. Approximately 9.3 ppm of total carbon was measured from the blank equilibration mobile phase following 10 days of continuous equilibration, which is considered to have been derived from the test system, tubing or atmospheric sources. A separate validation check of the total carbon reference standard was conducted following the total carbon calibration and sample analysis. The independent reference solution of 10 ppm provided a mean reference value of 11.5 ppm in the same analytic setup, providing independent validation of the TC calibration curve.
The water solubility of the test item was determined to be <3 mg/L based on net total carbon according to OECD 105 using the column equilibration method (modified).
Reference
Description of key information
Water Solubility was determined for the test item based on a saturation equilibrium using the column elution method. Total carbon analysis was performed following 5 to 11 days of equilibration. Total carbon measured from the equilibrated test item was 8.5 (+/- 4.1) ppm and total carbon measured from a blank DDI control was 9.8 ppm. From this assessment, no net carbon was recovered above the 3 ppm LOD for the test system. Approximately 9.3 ppm of total carbon was measured from the blank equilibration mobile phase following 10 days of continuous equilibration, which is considered to have been derived from the test system, tubing or atmospheric sources. A separate validation check of the total carbon reference standard was conducted following the total carbon calibration and sample analysis. The independent reference solution of 10 ppm provided a mean reference value of 11.5 ppm in the same analytic setup, providing independent validation of the TC calibration curve.
The water solubility of the test item was determined to be <3 mg/L based on net total carbon according to OECD 105 using the column equilibration method (modified).
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.