Registration Dossier
Registration Dossier
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EC number: 215-516-3 | CAS number: 1328-18-3 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 59805.
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
- Principles of method if other than guideline:
- BASF internal testing method
- GLP compliance:
- no
Test material
- Reference substance name:
- Anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione, bromo derivatives
- EC Number:
- 215-516-3
- EC Name:
- Anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione, bromo derivatives
- Cas Number:
- 1328-18-3
- Molecular formula:
- C34H14Br2O2
- IUPAC Name:
- anthra[9,1,2-cde]benzo[rst]pentaphene-5,10-dione, bromo derivatives
- Test material form:
- solid
- Details on test material:
- Vat Blue 19
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: talcum
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 mg - Duration of treatment / exposure:
- 1 hour
- Observation period (in vivo):
- 1, 24, 192 hours
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- SCORING SYSTEM:
Erythema and Edema
Ø - no effect
(+) - questionable
+ - mild
++ - moderate
+++ - marked
R - redness
Ö - oedema
N - necrosis
Tr - opacity
Na - scar
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 3
- Remarks on result:
- not determinable
- Remarks:
- blue staining, fully reversible within 8 d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Indigo: 1 hour: mild redness, mild edema, dark blue substance residues
24 hours: mild redness
192 hours: no effect
Talcum: 1 hour: mild redness, mild edema
24 hours: mild redness
192 hours: no effect
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The substance did not cause any significant signs of irritation in rabbit eyes. The substance is not classifiable.
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