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EC number: 945-481-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01/11/10 to 17/11/10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study performed according to international guidelines but not under GLP.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Remarks:
- The study has not been conducted for the purpose of REACH registration.
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of (E)-6-ethylidene-4a,5,6,7,8,8a-hexahydro-5,8-methano-4H-1-benzopyran and (E)-7-ethylidene-4a,5,6,7,8,8a-hexahydro-5,8-methano-4H-1-benzopyran and (Z)-7-ethylidene-4a,5,6,7,8,8a-hexahydro-5,8-methano-4H-1-benzopyran
- EC Number:
- 945-481-6
- IUPAC Name:
- Reaction mass of (E)-6-ethylidene-4a,5,6,7,8,8a-hexahydro-5,8-methano-4H-1-benzopyran and (E)-7-ethylidene-4a,5,6,7,8,8a-hexahydro-5,8-methano-4H-1-benzopyran and (Z)-7-ethylidene-4a,5,6,7,8,8a-hexahydro-5,8-methano-4H-1-benzopyran
- Test material form:
- liquid
- Details on test material:
- Batch No. 60352U002
Name of the test item (as cited in study report): OXATRICYCLO
Physical state: colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME ADMINISTERED: 1.95 mL/kg bw (corresponding to 2000 mg/kg bw)
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- - Step 1: 3 females (2000 mg/kg)
- Step 2: 3 females (2000 mg/kg) - Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing
Clinical signs and mortality: Animals were observed for any behavioural or toxic effects at 30 minutes, 1, 2, 3 and 4h after administration of the item and thereafter once a day until Day 14.
Bodyweight was recorded on Day-1, 4, 8 and 15 (i.e 3, 7, 14 days after administration of the test item)
- Necropsy of survivors performed: Yes; On Day 15, animals were anaesthetised with sodium pentobarbital 6% at a concentration of 1.16 mL/kg before a macroscopic examination. - Statistics:
- None
Results and discussion
- Preliminary study:
- Not Applicable
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no mortality was observed.
- Mortality:
- No mortality was observed.
- Clinical signs:
- Only slight piloerection was observed until 4h after administration of the test item. This effect was fully reversible.
No other clinical signs related to the administration of the test item were observed during the study. - Body weight:
- Body weight gain of the treated animals was not affected by test item.
- Gross pathology:
- No macroscopic abnormalities were observed at necropsy.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Conclusions:
- The oral LD50 for ETHYLIDENE-4a,5,6,7,8,8a-HEXAHYDRO-5,8-METHANO-4H-1-BENZOPYRAN MULTICONSTITUENT is higher than 2000 mg/kg bw in female rats therefore it is not classified according to Directive 67/548/EEC and CLP Regulation (EC) No 1272/2008.
- Executive summary:
In an acute oral toxicity study (limit test) performed according to OECD Guideline 423 and in compliance with GLP, 6 Sprague Dawley female rats were given a single oral (gavage) dose of ETHYLIDENE-4a,5,6,7,8,8a-HEXAHYDRO-5,8-METHANO-4H-1-BENZOPYRAN MULTICONSTITUENT at 2000 mg/kg bw. Animals were then observed for mortality, clinical signs and bodyweights for 14 days and were all sacrificed for macroscopic examination.
No mortality was observed. Body weight gain of the treated animals was not affected by test item. No macroscopic abnormalities were observed at necropsy. Slight piloerection, observed 4 h after administration of the test item, was fully reversible. In this study, the oral LD50 of ETHYLIDENE-4a,5,6,7,8,8a-HEXAHYDRO-5,8-METHANO-4H-1-BENZOPYRAN MULTICONSTITUENT was considered to be higher than 2000 mg/kg bw in female rats.
Therefore, ETHYLIDENE-4a,5,6,7,8,8a-HEXAHYDRO-5,8-METHANO-4H-1-BENZOPYRAN MULTICONSTITUENT is not classified according to Directive 67/548/EEC and CLP Regulation (EC) No 1272/2008.
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