Registration Dossier
Registration Dossier
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EC number: 255-137-0 | CAS number: 40908-37-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05.07.1996 to 12.05.1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
- EC Number:
- 255-137-0
- EC Name:
- N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
- Cas Number:
- 40908-37-0
- Molecular formula:
- C11H22N2O
- IUPAC Name:
- N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- corn oil
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 10 (5F/5M)
- Control animals:
- no
- Details on study design:
- Observation period: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no
- Clinical signs:
- other: There were no signs of systemic reaction to treatment.
- Gross pathology:
- No macroscopic abnormalities were detected apart from the local effects at the application site.
24 hours p.a. the skin of 7/10 animals showed well defined erythema and oedema. 48 hours p.a. an additional animal showed slight erythema and edema. Dryness of the skin was noted in eight animals (4 each sex). 72 hours p.a. scale formation was observed. Three days later erythema and edema were not noticed any more. Dryness and residual scales finally disappeared on day 12.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute lethal dermal dose (LD50) to rats of ACETYL-TAD was found to be greater than 2000 mg/kg bodyweight. Thus, the available data on acute dermal toxicity of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008, and are therefore conclusive but not sufficient for classification.
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