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Diss Factsheets
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EC number: 201-207-0 | CAS number: 79-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Supporting data were available, indicating that dichloroacetic acid is irritating to corrosive on rabbit skin and eye. Further testing is waived and most conservative classification as skin corrosive and irriversible effects in eyes are proposed.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1951
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication supporting the waiving arguments.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Type of coverage:
- not specified
- Remarks on result:
- other: Primary skin irritation on rabbits was 7/10.
- Remarks:
- no details reported
- Irritant / corrosive response data:
- slightly irritating
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Conclusions:
- The grade of primary irritation hazard given is explained by Smyth, Carpenter and Weil. Primary skin irritation on rabbits was 7/10.
- Executive summary:
Primary skin irritation grade on rabbits was 7/10 in a skin irritation and corrosion study in rabbits.
Therefore most conservatie classification as skin corrosive is proposed and further testing is avoided.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation
- Remarks:
- no data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1951
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Publication supporting the waiving arguments.
- Reason / purpose for cross-reference:
- reference to other study
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- no data
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- no data
- Details on study design:
- no data
- Remarks on result:
- other: strongly irritating
- Irritant / corrosive response data:
- strongly irritating
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information
- Conclusions:
- The grade of eye hazard given is explained by Carpenter and Smyth. Eye injury in rabbits from fluid was 10/10.
- Executive summary:
Eye iinjury in rabbits from fluid was 10/10, indicating highly corrosive activity. Therefore most conservatie classification as irriversible effects on the eyes is proposed and further testing is avoided.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A primary skin irritation grade on rabbits was 7/10 in a supporting skin irritation and corrosion study in rabbits (Smyth et al., 1951).Further testing is waived and most conservative classification as skin corrosive is proposed.
In the same supportive rabbit study , eye injury from fluid was 10/10, indicating highly corrosive activity (Smyth et al., 1951). Further testing is waived, and most conservatie classification as irriversible effects on the eyes is proposed.
Justification for selection of skin irritation / corrosion endpoint:
Supporting study for waiving arguments.
Justification for selection of eye irritation endpoint:
Supporting study for waiving arguments.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Justification for classification or non-classification
Dichloroacetic acid is classified as skin corrosive according to the Directive 67/548/EEC, Annex VI with symbol C (Corrosive) and risk phrase R35 -Causes severe burns. According to CLP regulation (No. 1272/2008 of 16 December 2008), dichloroacetic acid is classified as corrosive Category 1, with signal word 'Danger' and hazard statement: H314 - Causes severe skin burns and eye damage.
Dichloroacetic acid is classified as corrosive to eyes according to the Directive 67/548/EEC, Annex VI with symbol Xi and risk phrase R41- Risk of serious damage to eyes. According to CLP regulation (No. 1272/2/2008 of 16 December 2008), dichloroacetic acid is classified as Category 1, with signal word 'Danger' and hazard statement: H318 -Causes serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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