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EC number: 202-612-5 | CAS number: 97-85-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994 to 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- not specified
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- The exposure solutions for the test were prepared by direct addition of appropriate amounts of the test material to 500 mL volumetric flasks. Aliquots of each solution were transferred to the daphnid test vessels and served as exposure solutions. The test material solutions and diluent water controls were renewed each 24 hours. At each renewal period, the daphnids were transferred from the 24 hour old solutions to the renewed solutions. Samples of the renewal solutions and old solutions were sent for chemical analysis.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Daphnia magna were reared in-house and neonates betwee 6 and 24 hours old were used for testing.
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 120 mg/L
- Test temperature:
- 20 +/- 1 degree Celcius
- pH:
- 6.9 to 9.2
- Dissolved oxygen:
- 8.4 to 9.2
- Nominal and measured concentrations:
- Replicate A measured concentrations 53.72, 82.80, 109.10, 285.20 and 178. 15 mg/L and Replicate B measured concentrations 55.82, 70.30, 131.35, 227.08 and 32.85 mg/L. Nominal concetrations of 95.2, 171.5, 308.6, 555.5, and 1000 mg/L.
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 59.3 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- Replicate A
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 55.8 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- replicate B
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 53.7 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other:
- Remarks:
- replicate A
- Details on results:
- An NOEC value at 48 hours was not determinable for replicate B
- Reported statistics and error estimates:
- A computer program developed by C.E. Stephan and ASTM was used to compute point and interval estimaes of the EC50 values for this test. NOEC values were defined as the lowest analytzed concentration of the test material which resulted in effects which were not significantly different from those of the control group. Statistical signifiance was detected using an alpha level of 0.05.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The toxicity of the test material as measured by the 24, and 48-hr EC50 values, did not vary considerably over the course of the study. The 48-hr EC50 values for Daphnia magna for replicate series A and B were determined to be 59.3 mg/L and 55.8 mg/L, respectively.
- Executive summary:
An acute toxicity test with the aquatic invertebrate, Daphnia magna, was conducted following OECD 202 with expsoure to Isobutyl Isobutyrate. The 48 -hr EC50 values were reported for each of the two replicates as 59.5 and 55.8 mg/L, respectively. The geometric mean 48 -hr EC50 value is calculated as 57.5 mg/L.
Reference
Description of key information
An acute toxicity test with the aquatic invertebrate,Daphnia magna, was conducted following OECD 202 with expsoure to Isobutyl Isobutyrate. The 48 -hr EC50 values were reported for each of the two replicates as 59.5 and 55.8 mg/L, respectively. The geometric mean 48 -hr EC50 value is calculated as 57.5 mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 57.7 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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