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Diss Factsheets
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EC number: 208-964-6 | CAS number: 549-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Aquatic acute toxicity
Daphnia magna, water Flea, 48 h, EC50 = 4.82 mg/L
Spirostomum ambiguum (Protozoa), 48 h, EC50 = 0.41 mg/L
Fish, Danio rerio (Zebra Danio), 96 h, LC50 = 1.9 mg/L
Above data are selected from ECOTOX database of EPA.
LC50 (Sheepshead minnow, 4 days): 0.37 mg/l (this data has been taken by the SDS of the substance elaborated by EUROPEAN DIRECTORATE FOR THE QUALITY OF MEDICINES & HEALTHCARE, EDQM).
Spirotox is a short-term acute toxicity test with a large ciliated protozoan Spirostomum ambiguum. Spirotox was found to be very sensitive to heavy metals, fungicides, and pharmaceuticals used to cure diseases of the human nervous system. On the other hand, it was generally less sensitive than standard bioassays to simple organics (source: Nałecz-Jawecki G, Spirotox-Spirostomum ambiguum acute toxicity test-10 years of experience, Environ Toxicol. 2004).
Aquatic chronic toxicity
Adequate Chronic toxicity data are not available. In ECOTOX database of EPA one value of NOEC of 0.1 mg/L for fish (Danio rerio, Zebra Danio) is reported. This NOEC has been determined after 120 hr of exposure and the effect is mortality.
The following acute toxcicity data has been used for the classification of the substance for chronic hazards.
Daphnia magna, water Flea, 48 h, EC50 = 4.82 mg/L
Spirostomum ambiguum (Protozoa), 48 h, EC50 = 0.41 mg/L
Fish, Danio rerio (Zebra Danio), 96 h, LC50 = 1.9 mg/L
Above data are selected from ECOTOX database of EPA.
LC50 (Sheepshead minnow, 4 days): 0.37 mg/l (this data has been taken by the SDS of the substance elaborated by EUROPEAN DIRECTORATE FOR THE QUALITY OF MEDICINES & HEALTHCARE, EDQM)
Spirotox is a short-term acute toxicity test with a large ciliated protozoan Spirostomum ambiguum. Spirotox was found to be very sensitive to heavy metals, fungicides, and pharmaceuticals used to cure diseases of the human nervous system. On the other hand, it was generally less sensitive than standard bioassays to simple organics.
The logKow od the substance is 4.92.
Overall, the substance is classified as Aquatic Chronic 1.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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