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EC number: 203-761-9 | CAS number: 110-38-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
Link to relevant study record(s)
- Endpoint:
- relative density
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Juin 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.3 (Relative Density)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- other: Not specified
- Key result
- Type:
- relative density
- Density:
- 0.865 g/cm³
- Temp.:
- 20 °C
- Conclusions:
- According to the data of the certificate of analysis, the relative density of ethyl decanoate was assessed according to EC A3 method and was defined at 0.865 g/cm3 at 20°C.
- Endpoint:
- relative density
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Read-across category
- Justification for type of information:
- See "Assessment reports" section 13 or "Categories" section for the justification and rationale document for category approach.
- Key result
- Type:
- relative density
- Density:
- >= 0.853 - <= 0.879 g/cm³
- Temp.:
- 20 °C
- Conclusions:
- Based on the results from source chemicals of the category, the density of Ethyl decanoate ranges from 0.853 to 0.879 g/cm3 at 20°C.
Referenceopen allclose all
Table 1: Results from available key studies on the source substances of the category
Common name |
CAS |
Fatty acid chain length |
Type of alcohol |
MW |
Appareance |
Density |
Ethyl decanoate |
110-38-3 |
C10 |
ethanol |
200.32 |
Liquid |
Experimental result: 0.865g/cm3 at 20°C |
Ethyl undecylenate |
692-86-4 |
C11 |
ethanol |
212.33 |
liquid |
Experimental result: 0.878g/cm3 at 20°C |
Isopropyl laurate |
10233-13-3 |
C12 |
Isopropanol |
242,41 |
Liquid |
Experimental |
Octyl octanoate |
2306-88-9 |
C8 |
octanol (C8) |
256,42 |
Liquid |
Experimental |
Isopropyl myristate |
110-27-0 |
C14 |
Isopropanol |
270,46 |
Liquid |
Experimental result: 0.8532 g/cm³ at 20 °C |
Dodecanoic hexyl ester |
34316-64-8 |
C12 |
Hexanol (C6) |
284,49 |
Liquid |
(Q)SAR: |
Ethyl linoleate |
544-35-4 |
C18:2 |
ethanol |
308,5 |
Liquid |
Experimental |
Ethyl oleate |
111-62-6 |
C18:1 |
ethanol |
310.52 |
Liquid |
Experimental |
2-ethylhexyl laurate |
20292-08-4 |
C12 |
2-Ethylhexanol |
312,53 |
Liquid |
Experimental |
Fatty acids, coco, 2-ethylhexyl esters |
92044-87-6 |
C12-14 |
2-ethylhexanol |
312.53 – |
liquid |
Experimental result: 0.857 – |
Experimental results were obtained from studies performed on all the members of the category, except for dodecanoic hexyl ester, for which a QSAR was performed. The density values obtained in key studies ranged from 0.853 to 0.879 g/cm3 at 20°C. Due to structural similarities of these chemicals, the values are homogenous as expected.
Based on the relative density obtained for the category members, it can be deduced that the target substance, ethyl decanoate, has a density between 0.853 and 0.879g/cm3 at 20°C.
Description of key information
The density of ethyl decanoate was defined as 0.865 g/cm3 at 20°C.
Key value for chemical safety assessment
- Relative density at 20C:
- 0.865
Additional information
Justification and rationale of the category approach for Ethyl Caprate
This category group covers fatty acid chains linked to alcohols via an ester function. It includes mono-constituent substances and UVCB substances with varying fatty acid chain lengths from C8 to C18-unsaturated and alcohol types (including ethanol, isopropanol, octanol, hexanol and 2-ethylhexanol). This category group was made in order to provide sufficient information for physico-chemical, environmental, ecotoxicological and toxicological characterization of ethyl decanoate (CAS 110-38-3). Some data on the target substance of the category are available.
This category includes:
- Target substance:
o Ethyl decanoate (CAS 110-38-3)
- Source substances:
o Ethyl undecylenate (CAS 692-86-4)
o Isopropyl laurate (CAS 10233-13-3)
o Octyl octanoate (CAS 2306-88-9)
o Isopropyl myristate (CAS 110-27-0)
o Dodecanoic hexyl ester (CAS 34316-64-8)
o Ethyl linoleate (CAS 544-35-4)
o Ethyl oleate (CAS 111-62-6)
o 2-Ethylhexyl laurate (CAS 20292-08-4)
o Fatty acids, coco, 2-ethylhexyl esters (CAS 92044-87-6)
Summary of available information
All the source substances were assessed for density using handbook informations, QSAR or study performed according to OECD TG 109, ISO 2099 and EU Method A.3. Based on the results obtained for the category members, the density of the target substance ethyl decanoate was considered to be in the range of 0.853 to 0.879 g/cm3 at 20°C.
An experimental study on the target substance, Ethyl decanoate, was also performed according to EU Method A.3 (only method and results provided) and it gives a value of 0.865 g/cm3 at 20°C.
Conclusions
According to the Regulation (EC) NO. 1907/2006, Annex XI, 1.5, a Read-Across Category for " Medium Chain Fatty Acid (from C8 to C18 unsat.) and alcohol esters (from C2 to C8) was performed in order to provide information on Ethyl Caprate.
This category was based on common and shared properties as:
- common functional group,
- common precursors and the likelihood of common impurities resulting from common process of manufacturing,
- chemically structurally similar breakdown products obtained via the same biological processes into the organisms, and
- constant pattern in the changing of the potency of the properties across the category.
Based on the relative density obtained for the category members, it can be deduced that the target substance has a density between 0.853 to 0.879 g/cm3 at 20°C. Additionaly an experimental study on the target substance, Ethyl decanoate, was also performed and it gives a relative density of 0.865 g/cm3 at 20°C. This value was within the expected range given by the category approach based on the structural similarities between source chemicals and target substance. Hence, this experimental value of 0.865 g/cm3 is considered relevant for the relative density assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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