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Diss Factsheets
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EC number: 947-474-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication, similar to guideline, a subchronic study was taken to determine the acute LD50 value based on the resulting NOAEL value
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD guideline 453
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- other: subchronic study
- Limit test:
- no
Test material
- Reference substance name:
- α-d-Glucopyranoside, β-d-fructofuranosyl, octadecanoate
- EC Number:
- 253-459-6
- EC Name:
- α-d-Glucopyranoside, β-d-fructofuranosyl, octadecanoate
- Cas Number:
- 37318-31-3
- Molecular formula:
- C18 H36 O2 . x C12 H22 O11
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344/DuCrj
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Japan Inc.
- Age at study initiation: 5 weeks old at the start of treatment
- Housing: Polycarbonate cages with hardwood chip bedding were used, and in each housed two animals
- Diet: radiation-sterilized powder feed, CRF-1, Oriental Yeast Co., Ltd. ad libitum, replaced weekly, feed mix was prepared twice during the study (1 week before the start of administration and 5 weeks later).
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 20-25 °C
- Humidity: 40-70 %
- Air changes: 12 changes/h
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: CRF-1
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 % in feed equivalent to 3240 mg/kg bw/day males and 3430 mg/kg bw/day females.
- Doses:
- 636, 1900 and 3240 mg/kg bw/day (males)
666, 1950 and 3430 mg/kg bw/day (females) - No. of animals per sex per dose:
- groups of 20 per sex
- Control animals:
- yes
- Details on study design:
- - Duration of observation period: 13 weeks
- Frequency of observations: Daily, weekly, before the end of treatment
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: Ophtalmology, Urinalysis - Statistics:
- Bartlett´s equal variance test
Analysis of variance (ANOVA)
Dunnett´s method
Scheffé´s method
Kruskal-Wallis H test
Amitage´s x^2 test
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 3 240 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Results based on subchronic study
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 3 430 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Results based on subchronic study
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No clinical signs were observed
- Gross pathology:
- No effects were observed
- Other findings:
- - Organ weights: Male animals showed a significant decrease in absolute kidney weight in the medium- and high-dose groups and a decrease in relative kidney weights in all treated groups. A significant decrease of relative liver weight was also observed in the male high-dose group.
- Food consumption: An increase in food consumption was noted in the male animals of the high-dose group near the end of the adminsitration period.
- Histopathology: NON-NEOPLASTIC: Extramedullary hematopoesis of the spleen was observed.
- Other observations: URINANALYSIS: Ketone bodies in the urine were decreased in male animals of the high-dose group.
The effects described above were judged to be not based on compound related effects. The study demonstrated that the test substance was not toxic in Fischer rats.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.