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EC number: 911-418-6 | CAS number: 55965-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
- Version / remarks:
- January 2006
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- batch equilibrium method
- Media:
- soil
Test material
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Rohm and Haas, Batch No. 1063.0009
RADIOLABELLING INFORMATION (if applicable)
- Radiochemical purity: 96.9%
- Specific activity: 48.5 mCi/g
- Locations of the label: 14C label was at the 4 and 5 position
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Not described
- Stability under test conditions: Confirmation of parent stability examined by TLC
- Solubility and stability of the test substance in the solvent/vehicle: Water solubility > 1000 ppm
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: No
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Treatment of test material prior to testing: 14C MIT, 29.43 mg (1.43 mCi or 52.8 MBq) was initially dissolved in 25 ml of sterile deionized water (nominal 1000 mg/L). A test concentrate solution was prepared by adding the above stock solution to a solution of 0.01M CaCl2.
- Final dilution of a dissolved solid, stock liquid or gel: 5 mg 14C-MIT/L solution with 0.01M CaCl2
FORM AS APPLIED IN THE TEST (if different from that of starting material)
Liquid - Radiolabelling:
- yes
Study design
- Test temperature:
- Not described
Batch equilibrium or other method
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 5 mg/L
- Sampling interval: 2, 4, 8, 24, and 48 hrs
- Sample storage before analysis: Not described
Matrix propertiesopen allclose all
- Matrix no.:
- #1
- Matrix type:
- sandy loam
- % Clay:
- 15
- % Silt:
- 17
- % Sand:
- 68
- % Org. carbon:
- 1.3
- pH:
- 6.2
- CEC:
- 11.5 meq/100 g soil d.w.
- Matrix no.:
- #2
- Matrix type:
- clay loam
- % Clay:
- 36
- % Silt:
- 22
- % Sand:
- 42
- % Org. carbon:
- 3.9
- pH:
- 6.5
- CEC:
- 27.4 meq/100 g soil d.w.
- Matrix no.:
- #3
- Matrix type:
- silty clay loam
- % Clay:
- 31
- % Silt:
- 57
- % Sand:
- 12
- % Org. carbon:
- 2.1
- pH:
- 5
- CEC:
- 13.8 meq/100 g soil d.w.
- Matrix no.:
- #4
- Matrix type:
- sand
- % Clay:
- 4
- % Silt:
- 4
- % Sand:
- 92
- % Org. carbon:
- 0.3
- pH:
- 4.7
- CEC:
- 1.8 meq/100 g soil d.w.
- Matrix no.:
- #5
- Matrix type:
- loam
- % Clay:
- 20
- % Silt:
- 36
- % Sand:
- 44
- % Org. carbon:
- 16.8
- pH:
- 7.4
- CEC:
- 60.4 meq/100 g soil d.w.
- Details on matrix:
- COLLECTION AND STORAGE
- Geographic location:
Hyde Farm Pickneys Green, Maidenhead, Berks, UK (sandy loam)
Pickett Piece Manor Farm, Oxfordshire, UK (clay loam)
Naldrett Farm Wisborough Green, Sussex, UK (silty clay loam)
Lillifield Wishanger Farm, Churt, Surrey, UK (sand)
Kenny Hill Farm, Mildenhall, Suffolk, UK (loam)
- Sampling depth (cm): Top 20 cm of agricultural land
- Soil preparation (e.g.: 2 mm sieved; air dried etc.): Air dried, passed through a 2 mm sieve, and sterilized by gamma irradiated prior to use - Details on test conditions:
- TEST CONDITIONS
- Buffer: No
- pH: 6.2 (sandy loam), 6.5 (clay loam), 5.0 (silty clay loam), 4.7 (sand) and 7.4 (loam)
TEST SYSTEM
- Type, size and further details on reaction vessel: 50 ml PTFE centrifuge tubes
- Water filtered (i.e. yes/no; type of size of filter used, if any): No
- Amount of soil/sediment/sludge and water per treatment (if simulation test): 20 g of one of the five soils was added and 20 ml of 5mg 14C-MIT/L of 0.01M CaCl2
- Soil/sediment/sludge-water ratio (if simulation test): 1:1
- Number of reaction vessels/concentration: 3
- Measuring equipment: Liquid scintillation counter, Thin layer chromatography
- Test performed in closed vessels due to significant volatility of test substance: No
- Test performed in open system: Yes
- Method of preparation of test solution: Dilution in matrix
- Are the residues from the adsorption phase used for desorption: Yes
Duration of adsorption equilibrationopen allclose all
- Duration:
- 2 h
- Initial conc. measured:
- 5 other: mg/L
- Duration:
- 4 h
- Initial conc. measured:
- 5 other: mg/L
- Duration:
- 8 h
- Initial conc. measured:
- 5 other: mg/L
- Duration:
- 24 h
- Initial conc. measured:
- 5 other: mg/L
- Duration:
- 48 h
- Initial conc. measured:
- 5 other: mg/L
Duration of desorption equilibrationopen allclose all
- Sample no.:
- #1
- Duration:
- 2 h
- Conc. of adsorbed test mat.:
- 0.525 other: mg/L
- pH:
- 6.2
- Remarks:
- Sandy loam
- Sample no.:
- #2
- Duration:
- 2 h
- Conc. of adsorbed test mat.:
- 1.235 other: mg/L
- pH:
- 6.5
- Remarks:
- Clay loam
- Sample no.:
- #3
- Duration:
- 2 h
- Conc. of adsorbed test mat.:
- 0.8 other: mg/L
- pH:
- 5
- Remarks:
- Silty clay loam
- Sample no.:
- #4
- Duration:
- 2 h
- Conc. of adsorbed test mat.:
- 0.095 other: mg/L
- pH:
- 4.7
- Remarks:
- Sand
- Sample no.:
- #5
- Duration:
- 2 h
- Conc. of adsorbed test mat.:
- 2.3 other: mg/L
- pH:
- 7.4
- Remarks:
- Loam
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Sample No.:
- #1
- Type:
- Kd
- Value:
- 0.1 dimensionless
- pH:
- 6.2
- Matrix:
- Sandy loam
- % Org. carbon:
- 1.3
- Key result
- Sample No.:
- #2
- Type:
- Kd
- Value:
- 0.27 dimensionless
- pH:
- 6.5
- Matrix:
- Clay loam
- % Org. carbon:
- 3.9
- Key result
- Sample No.:
- #3
- Type:
- Kd
- Value:
- 0.14 dimensionless
- pH:
- 5
- Matrix:
- Silty clay loam
- % Org. carbon:
- 2.1
- Key result
- Sample No.:
- #4
- Type:
- Kd
- Value:
- 0.03 dimensionless
- pH:
- 4.7
- Matrix:
- Sand
- % Org. carbon:
- 0.3
- Key result
- Sample No.:
- #5
- Type:
- Kd
- Value:
- 1.07 dimensionless
- pH:
- 7.4
- Matrix:
- Loam
- % Org. carbon:
- 16.8
- Key result
- Sample No.:
- #1
- Type:
- Koc
- Value:
- 7.7 dimensionless
- pH:
- 6.2
- Matrix:
- Sandy loam
- % Org. carbon:
- 1.3
- Key result
- Sample No.:
- #2
- Type:
- Koc
- Value:
- 6.9 dimensionless
- pH:
- 6.5
- Matrix:
- Clay loam
- % Org. carbon:
- 3.9
- Key result
- Sample No.:
- #3
- Type:
- Koc
- Value:
- 6.7 dimensionless
- pH:
- 5
- Matrix:
- Silty clay loam
- % Org. carbon:
- 2.1
- Key result
- Sample No.:
- #4
- Type:
- Koc
- Value:
- 10 dimensionless
- pH:
- 4.7
- Matrix:
- Sand
- % Org. carbon:
- 0.3
- Key result
- Sample No.:
- #5
- Type:
- Koc
- Value:
- 6.4 dimensionless
- pH:
- 7.4
- Matrix:
- Loam
- % Org. carbon:
- 16.8
Results: Batch equilibrium or other method
- Adsorption and desorption constants:
- Koc (adsorption) = 7.7 (sandy loam), 6.9 (clay loam), 6.7 (silty clay loam), 10 (sand) and 6.4 (loam)
- Recovery of test material:
- The range of average recoveries was 90.4% to 119.1%
Mass balance (%) at end of desorption phaseopen allclose all
- Sample no.:
- #1
- Duration:
- 2 h
- % Desorption:
- 34.3
- Remarks on result:
- other: Sandy loam
- Sample no.:
- #2
- Duration:
- 2 h
- % Desorption:
- 16.7
- Remarks on result:
- other: Clay loam
- Sample no.:
- #3
- Duration:
- 2 h
- % Desorption:
- 10.6
- Remarks on result:
- other: Silty clay loam
- Sample no.:
- #4
- Duration:
- 2 h
- % Desorption:
- 26.3
- Remarks on result:
- other: Sand
- Sample no.:
- #5
- Duration:
- 2 h
- % Desorption:
- 14.7
- Remarks on result:
- other: Loam
- Transformation products:
- not measured
- Remarks:
- Due to the low concentration the degradation products were not determined.
- Details on results (Batch equilibrium method):
- PRELIMINARY TEST
- Weighed soil: 20, 4 or 0.8 g per 20 mL CaCl2 solution
- Volume of CaCl2 solution: 20 mL
- Test substance concentration in final solution: 5 mg/L
- Analytical test substance concentration in final solution: 5 mg/L
MAIN TEST: PERFORMANCE
- Test material stability during adsorption/desorption phase: Yes
- Experimental conditions maintained throughout the study: Yes
- Buffer/test substance interactions affecting sorption: No
- Further chemical interactions: No
- Buffer-catalyzed degradation of test substance: No
RESULTS OF SUPPLEMENTARY EXPERIMENT (if any): PTFE centrifuge tubes were chosen for all experiments as there was no significant adsorption to this material. At a soil:solution ratio of 1:25, there was essentially no adsorption of MIT to either soil. There was a slight adsorption at a ratio of 1:5 for the loam soil but again essentially none for the clay loam. At a soil:solution ratio of 1:1 both soils showed significant adsorption. Thus a ratio of 1:1 was employed for all further experiments.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The study provided is satisfactory to describe the mobility of MIT in soil. According to the US EPA classification scheme, MIT is considered highly mobile. However, due to its rapid biodegradation in soil (half-life is 6.5 hours), it is unlikely that parent mobility will be an environmental concern.
- Executive summary:
The test guideline followed was OECD 106. There were no deviations from this test guideline. All five soils were gamma irradiated prior to dosing to enhance sterility and prevent biodegradation of MIT during the course of the experiment.Initially14C-MIT was added to 50 ml PTFE centrifuge tubes and it was determined that after 48 hours of mixing there was no significant adsorption to the containers. A second experiment to determine the soil:solution ratio was performed with the clay loam and loam soils. Ratios examined were 1:1, 1:5, and 1:25 and the MIT concentration was 5 mg/L. After 22 hours the samples were radioassayed to determine the amount of MIT adsorbed to the soil. A third experiment determined the kinetics of adsorption for all five soils at a soil:solution ratio of 1:1 and dosing with 5mg14C-MIT/L 0.01M CaCl2. Samples were radioassayed after 2, 4, 8, 24, and 48 hrs of equilibration. A fourth experiment was performed to determine the desorption parameters of MIT. Five soils were dosed with 5 mg14C-MIT/L 0.01M CaCl2and after 2 hrs of equilibration the14C solution was removed and replaced with 0.01M CaCl2. After 2, 4, 24, and 48 hours of mixing, the amount of14C-activity desorbed was determined by radioassay. In the final experiment, the isotherm parameters were determined in all 5 soils and using dosing concentrations of 5, 1, 0.2, 0.04, and 0.008 mg14C-MIT/L 0.01M CaCl2. After 2 hours the concentration of14C activity in the solution and sediment phases was determined. In addition, the mass balance was determined for these samples.Aliquots from the soil:solution and the kinetic experiments were analyzed by TLC to determine stability of MIT. MIT was not highly adsorbed to any of the 5 soils examined. The system was found to reach equilibrium within 2 hrs and under these conditions MIT was stable in these soil:solution systems. It was determined that a soil:solution ratio of 1:1 was necessary since there was marginal if any soil adsorption at ratios of 1:5 and 1:25. Mass balance was determined for the clay loam and loam soils and the average recovery 92.66 ± 3.44% and 107.17 ± 15.11%, respectively.
After a 2 hour equilibration period in the kinetics test the percent14C-activity detected as MIT by TLC ranged from 88.9% (loam) to 97.3% (silty clay loam and soil-less control). Due to the low concentration the degradation products were not determined.
The study provided is satisfactory to describe the mobility of MIT in soil. According to the US EPA classification scheme, MIT is considered highly mobile. However, due to its rapid biodegradation in soil (half-life is 6.5 hours), it is unlikely that parent mobility will be an environmental concern.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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