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EC number: 222-248-0 | CAS number: 3396-11-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Jan 7, 1997 to Jan 30, 1997
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Pesticide Assessment Guidelines, Subdivision F (81-1) EPA Health Effects Testing Guidelines (TSCA Guideline No. 798.1175)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- other: Albino rats
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Naive, young adult male and female Sprague-Dawleyd eriveda lbino rats weighing 198-303 g were used. The animals were purchase from a vendor who equals or exceeds U.S.D.A. standards even though rats are not regulated animals. All animals were acclimated to the laboratory for at least five days before being used. Animals were housed in groups of five in wire mesh suspension cages and were supplied Teklad 4% mouse/rat diet and tap water ad libitum during both acclimation and test periods except for withholding food overnight prior to dosing. The animal room was maintained on a 12 h light/12 h dark cycle and at a temperature of 64-79°F and a relative humidity of 30-70%. There were no contaminants in either the feed or the water that were expected to affect the outcome of this study.
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- The test substance was administered by gavage.
- Doses:
- 1250, 1580, 2000 and 5000 mg/kg bw
- No. of animals per sex per dose:
- Forty animals (five/sex/dose level)
- Control animals:
- no
- Details on study design:
- Overnight prior to dosing, food (but not water) was withheld from the rats. The time of fasting and dosing was documented. Groups of five male and five female rats received the test substance by gavage at varying dose levels so that a median lethal dose could be calculated. Four groups were used for the study. The test substance was administered undiluted using the bulk density to determine the dose volume. Individual doses were calculated using post-fast body weights.
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 550 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 1 450 - ca. 1 660
- Mortality:
- Based on the cumulative mortality observed during the 14 d observation period following a single oral dose of undiluted test substance the acute oralLD50 value was calculated to be 1550 mg/kg bw with 95% Confidence Intervals of 1450 mg/kg bw and 1660 mg/kg bw.
- Clinical signs:
- other: Clinical signs noted during the observation period included varying degrees of depression, convulsions, respiratory distress, excess salivation, gross signs of distress, diarrhea, and external staining. Clinical signs were noted at all dose levels investi
- Gross pathology:
- Gross necropsy findings for animals that died during the observation period included those generally seen in agonal animals indications of gastro-intestinal irritation, and external staining. There were no gross pathological changes observed in animals which survived the 14 d observation period.
- Conclusions:
- Under the study conditions, the acute oral LD50 value of the test substance in rats was calculated to be 1550 mg/kg bw.
- Executive summary:
A study was conducted to assess the acute oral toxicity of the test substance according to OECD 401 and EPA Pesticide Assessment Guidelines, Subdivision F (81-1) EPA Health Effects Testing Guidelines (TSCA Guideline No. 798.1175), in compliance with GLP. The substance was administered undiluted to groups of five male and five female Sprague Dawley rats at dose levels of 0, 1250, 1580, 2000 and 5000 mg/kg bw. Animals were then observed for 14 d. Clinical signs included varying degrees of depression, convulsions, respiratory distress, excess salivation, gross signs of distress, diarrhea and external staining. Clinical signs were noted at all dose levels, however only faecal staining was seen at 1250 mg/kg bw. All surviving animals exhibited bodyweight gain at Day 14. Gross necropsy findings for animals that died during the observation period included those generally seen in agonal animals, i.e. indications of gastro-intestinal irritation and external staining. There were no gross pathological changes in animals which survived the 14 d observation period. Under the study conditions, the acute oral LD50 value of the test substance in rats was calculated to be 1550 mg/kg bw (Harrod, 1997).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 550 mg/kg bw
Additional information
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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