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EC number: 618-690-2 | CAS number: 90982-32-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in air
Administrative data
- Endpoint:
- phototransformation in air
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Photolysis of the radiolabeled test substance was studied in sterilized aqueous solutions which were buffered to pH 5, 7, and 9. The degradation of the test substance solutions exposed to simulated sunlight was compared to degradation of control solutions maintained in darkness. The temperature of all test solutions was kept at 25°C.
- GLP compliance:
- no
Test material
- Reference substance name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- EC Number:
- 618-690-2
- Cas Number:
- 90982-32-4
- Molecular formula:
- C15H15ClN4O6S
- IUPAC Name:
- ethyl 2-({[(4-chloro-6-methoxypyrimidin-2-yl)carbamoyl]amino}sulfonyl)benzoate
- Test material form:
- solid
- Remarks:
- White
- Details on test material:
- 95 to >99% purity
Constituent 1
Study design
- Light source:
- other: simulated sunlight
- Light spectrum: wavelength in nm:
- ca. 300 - ca. 450
- Details on light source:
- A bank of lights consisting of 6 fluorescent sunlamps alternating with 6 fluorescent black lamps spaced 2 inches between lamp centers was set 6 inches above the surface of the test solutions. The average light intensity (300-450 nm) was 45.5 watts/m2 at a distance of 6-1/2 inches below the lamps.
Duration of test at given test conditionopen allclose all
- Duration:
- 10 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.5 other: ppm
- Duration:
- 10 d
- Temp.:
- 25 °C
- Initial conc. measured:
- 5 other: ppm
- Reference substance:
- yes
- Remarks:
- ethyl 2-(aminosulfonyl)benzoate and 4-chloro-6-methoxy-2-pyrimidinamine
Results and discussion
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- No.:
- #3
Reference
- Reference substance name:
- Unnamed
Applicant's summary and conclusion
- Conclusions:
- The photodegradation of the test substance proceeded rapidly with a first half-life of about 2 days in all solutions exposed to light. Degradation of the dark controls was dependent on the pH of the test solution with half-lives ranging from 18 days to greater than 30 days. At the most hydrolytically stable pH (i.e. pH 9), photolysis of the test substance resulted in ethyl 2-[[[[(4-hydroxy- 6-methoxy-pyrimidin-2 -yl)amino]carbonyl]amino]sulfonyl]benzoate, N-[10-oxo-10H-[4,1]-benzoxathiepin[3,2-d]-6-methoxy- pyrimidin-2-yl]urea, S,S-dioxide, and [2-[[(amino)-carbonyl]amino]-6-methoxy-4-pyrimidinyl] 2-sulfobenzoate.
- Executive summary:
Photolysis of the radiolabeled test substance was studied in sterilized aqueous solutions which were buffered to pH 5, 7, and 9. The degradation of the test substance solutions exposed to simulated sunlight was compared to degradation of control solutions maintained in darkness. The temperature of all test solutions was kept at 25°C.
The photodegradation of the test substance proceeded rapidly with a first half-life of about 2 days in all solutions exposed to light. Degradation of the dark controls was dependent on the pH of the test solution with half-lives ranging from 18 days to greater than 30 days. At the most hydrolytically stable pH (i.e. pH 9), photolysis of the test substance resulted in ethyl 2-[[[[(4-hydroxy- 6-methoxy-pyrimidin-2 -yl)amino]carbonyl]amino]sulfonyl]benzoate, N-[10-oxo-10H-[4,1]-benzoxathiepin[3,2-d]-6-methoxy- pyrimidin-2-yl]urea, S,S-dioxide, and [2-[[(amino)-carbonyl]amino]-6-methoxy-4-pyrimidinyl] 2-sulfobenzoate.
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