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EC number: 202-461-5 | CAS number: 95-87-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 968
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The acute toxicity of 4 solid, crystalline xylenol isomers including 2,5-xylenol was studied in white mice, albino rats, and rabbits. A single dose of the substances was administered by mouth in the form of finely dispersed aqueous suspensions. The animals were kept under clinical observation for 15 days. Data on rat and mice mortality were processed statistically by probit analysis as modified by Prozorovsky (1962). LD50 for rabbits was determined by the method of Deichmann and Le Blanc (1943).
- GLP compliance:
- no
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,5-xylenol
- EC Number:
- 202-461-5
- EC Name:
- 2,5-xylenol
- Cas Number:
- 95-87-4
- Molecular formula:
- C8H10O
- IUPAC Name:
- 2,5-dimethylphenol
- Test material form:
- solid: crystalline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino rats
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- water
- Details on oral exposure:
- A single dose of 2,5-xylenol was administered by mouth in the form of a finely dispersed aqueous suspension of the solid, cristalline material.
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- The acute toxicity of 2,5-xylenol was studied in white mice, albino rats, and rabbits. A single dose of the substance was administered by mouth in the form of a finely dispersed aqueous suspension of the solid, cristalline material. The animals were kept under clinical observation for 15 days.
- Statistics:
- Mortality data of rats and mice were processed statistically by probit analysis as modified by Prozorovsky; LD50 for rabbits was determined by the method of Deichmann and Le Blanc (1943).
References:
Deichmann W, LeBlanc T (1943) Determination of the approximate lethal dose with about 6 animals. J Ind Hyp Toxicol 25, 415-417.
Prozorovsky VB (1962) Application of a method of least squares for probit-analysis of the lethality curves // Farmakol. i toksikol. - 1962. -N9l. - P. 115-120 (in Russian).
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- species: rat
- Effect level:
- ca. 444 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- S:E. 26 mg/kg bw
- Mortality:
- Most of the animals with acute poisoning died within 24 hours of administration.
- Clinical signs:
- other: The clinical picture was similar in all the species of laboratory animals investigated (and for all of the 4 isomers considered). The clinical signs of acute poisoning were dyspnea, disturbance of motor coordination, a rapid advent of clonic spasms, and a
- Gross pathology:
- no data
Any other information on results incl. tables
Species |
LD50-values (mg/kg bw ± standard error if indicated) |
White mice |
383 ± 36 |
Albino rats |
444 ± 26 |
Rabbits |
938 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- 2,5-Xylenol showed slight acute oral toxicity, with a rat LD50 value of 444 ± 26 (S.E.) mg per kg body weight.
- Executive summary:
The acute toxicity of 4 solid, crystalline xylenol isomers including 2,5-xylenol was studied in white mice, albino rats, and rabbits in accordance with international accepted scientific methods. No guideline was followed. A single dose of the substances was administered by mouth in the form of finely dispersed aqueous suspensions. The animals were kept under clinical observation for 15 days. Data on rat and mice mortality were processed statistically by probit analysis as modified by Prozorovsky (1962). LD50 for rabbits was determined by the method of Deichmann and Le Blanc (1943). The clinical picture was similar in all the species of laboratory animals investigated (and for all the isomers considered). The clinical signs of acute poisoning were dyspnea, disturbance of motor coordination, a rapid advent of clonic spasms, and an asymmetrical body position. Most of the animals with acute poisoning died within 24 hours of administration.
Based on the study results, LD50values of 383 ±36 (S.E.), 444 ± 26, and 938 mg/kg bw were calculated for white mice, albino rats and rabbits, respectively.
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