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EC number: 294-589-3 | CAS number: 91744-27-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: A study, similar to OECD401 was performed with the read-across substance CAS 91744-44-4: LD50> 5000 mg/kg bw
Acute dermal toxicity: OECD402: LD50> 2000 mg/kg bw
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity (CAS 91744-44-4)
In a study similar to OECD 401, the acute oral toxicity of the test item was assessed in TNO Wistar rats. Using propylene glycol as vehicle, the test item was administrated orally at a single dose of 5000 mg/kg on an empty stomach. 10 rats (5 female and 5 male) were used for the study. After administration of the test item, the animals were observed for 14 days. Deaths and clinical symptoms were recorded and necropsy was performed. The first five hours of application the animals had an ruffle fur, no other clinical signs were recorded and no deaths occurred during the 14 day observation period. The only observation at necropsy was hydrometra in one animal. Based on these data, the LD50 was above 5000 mg/ kg bw/day. Therefore, the substance is not considered to be acutely harmful (BASF, 1984).
Acute dermal toxicity (CAS 91744 -27-3)
In a study performed according to OECD 402 and GLP, the acute dermal toxicity of the test item was assessed in Wistar Crl:WI (Han) SPF rats. A dose of 2000 mg/kg bw undiluted substance was applied to about 40 cm² clipped dorsal and dorsolateral parts of the trunk of 5 males and 5 female animals for 24 hours under semi-occlusive conditions. The test substance was removed with warm water and the animals were observed for 14 days. Mortality, clinical symptoms and bodyweight were recorded and necropsy with gross-pathology examination was performed. In addition, skin findings were scored. No mortality occurred and no systemic clinical signs were observed during clinical examination of both sexes. The body weights of the male and animals increased within the normal range throughout the study period, with the exception of two females in the first week after exposure. However, these observations were considered unspecific. Very slight erythema (grade 1) was observed in three male and four female animals from study day 1 until study day 2 or 3. Based on these data, the LD50 was above 2000 mg/ kg bw/day. Therefore, the substance is not considered to be acutely harmful (Bioassay, 2017).
Justification for classification or non-classification
Based on the available data no classification and labelling is warranted for acute oral and dermal toxicity in accordance with EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008
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