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EC number: 500-258-9 | CAS number: 74775-06-7 1 - 2.5 moles propoxylated
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A study to determine acute dermal toxicity was deemed not to be scientifically necessary for PPG-2 myristyl ether propionate. This is based on existing information presented in an acute oral test and an in vivo dermal irritation test that indicate a lack of toxicity. Following a 14-day in vivo toxicity study in Wistar-derived albino rats, it was found that oral administration of PPG-2 myristyl ether propionate at 5 g/kg did not result in any mortality or symptoms of toxicity. Subsequently, an LD50 of >5 g/kg was assigned to the substance and classification was demonstrated not to be necessary (CLP Regulation (EC) No. 1272/2008).
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July 14, 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: Acute Toxicity
- Version / remarks:
- Method by Hagen, E. C. (1959) in Appraisal of the Safety of Chemicals in Food, Drugs, and Cosmetics. Division of Pharmacology, Food and Drug Administration, Department of Health, Education, and Welfare, 17 - 25
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Wistar-derived albino rats
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Summit View Farm, Belvidere, New Jersey (conditioned prior to use)
- Weight at study initiation: 186 - 242 g
- Fasting period before study: Fasted overnight prior to test material administration
- Diet: Ad libitum with Wayne animal feed
- Water: Ad libitum
- Acclimation period: Maintained under standard laboratory conditions for a minimum of seven days prior to test material administration - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Single dose of 5 g/kg bw
- No. of animals per sex per dose:
- Five male and five female rats were dosed individually
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations for signs of pharmacologic activity and drug toxicity at 1, 3, 6, and 24 hours post-dosage and thereafter on each day
- Necropsy of survivors performed: Complete gross necropsy performed at the conclusion of day 14 - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 other: g/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Following an in vivo 14-day toxicity study in rats via the oral route, PPG-2 myristyl ether propionate was found not to have induced any symptoms of toxicity and was subsequently assigned an LD50 of >5 g/kg bw. Classification in line with CLP Regulation (EC) No. 1272/2008 is not required.
- Executive summary:
An in vivo acute toxicity study via the oral route was undertaken in mixed sex Wistar-derived albino rats over a 14-day period according to the procedure recommended by Hagan (1959) in the Appraisal of the Safety of Chemicals in Foods, Drugs, and Cosmetics. Following an overnight fasting period, a single dose of 5 g/kg PPG-2 myristyl ether propionate was administered by gavage according to bodyweight. Food and water were available ad libitum. All rats were observed for pharmacologic activity and toxicity at 1, 3, 6, and 24 hours post-dosage and thereafter on day 2, 3, 4, 5, 6, 7, and 14. Animals were then sacrificed and subjected to complete gross necropsy at the termination of the experiment. Over the study, no rats perished and no symptoms of toxicity were observed. Consequently, PPG-2 myristyl ether propionate was concluded not to be a toxic substance under the conditions of the test with an assigned LD50 of >5 g/kg bw. Hazard classification was not required (CLP Regulation (EC) No. 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Justification for type of information:
- A study was performed to determine the vapour pressure of PPG-2 myristyl ether propionate. Using the isoteniscope technique, a final value of < 100 Pa at 20 °C was calculated as the mean of three replicates. Taking account of the low vapour pressure of the substance, testing for acute toxicity by the inhalation route is not deemed appropriate in accordance with REACH Annex VIII, 8.5.2.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The endpoint value for acute oral toxicity was attained from a key study that was undertaken according to a protocol described by Hagan (1959) that was published by the United States Division of Pharmacology, Food and Drug Administration (Department of Health, Education, and Welfare). The experiment occurred prior to the U.S. Good Laboratory Practise (GLP) regulations (21 CRF Part 58) that became effective in June 1979. The final conclusion has been assigned a Klimisch score of 2 (reliable with restrictions) given that the study is based on a standard guideline and its restrictions have been concluded to be acceptable.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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