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EC number: 915-600-6 | CAS number: 64553-79-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read across to an analogue substance: Reliable in vivo skin and eye irritation studies using rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH : Please see attached Read Across supporting document in Section 13 which includes the following:
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
3. ANALOGUE APPROACH JUSTIFICATION
4. DATA MATRIX - Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: overall at 24.5, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24.5, 48 and 72 h
- Score:
- 0
- Max. score:
- 4
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on read across to an in-vivo study for an analogue substance, Solvent Blue 79 is predicted to be non-irritating to the skin. This material would not be classified under EU regulations.
- Executive summary:
A read across approach was used to an analogue substance; Solvent Blue 98, which has a similar composition/structure. (Please see read across justification document for more information)
The skin irritation potential of the analogue material was evaluated in New Zealand White rabbits. There were no irritative effects observed in any of the animals at any time-point. All animals appeared normal throughout the course of the study. The individual animal mean scores for the 24.5, 48 and 72 hr time-point for the intact skin indicated that this material would not be classified under EU regulations.
Based on the analogue read across approach, the target substance Solvent Blue 79 is predicted to be non irritating to skin.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH : Please see attached Read Across supporting document in Section 13 which includes the following:
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
3. ANALOGUE APPROACH JUSTIFICATION
4. DATA MATRIX - Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 3
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.56
- Max. score:
- 4
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on read across to an in-vivo study for an analogue substance, Solvent Blue 79 is predicted to be non-irritating to the eyes. This material would not be classified under EU regulations.
- Executive summary:
A read across approach was used to an analogue substance; Solvent Blue 98, which has a similar composition/structure.
(Please see read across justification document for more information)
The primary ocular irritation potential of the analogue material was evaluated in New Zealand White rabbits. One group of six albino rabbits received a single, unwashed exposure. A 0.1- ml dose of the test article was instilled into the lower conjunctival sac of one eye. The eyelids were held together for approximately one second and released. The other eye served as an untreated control. The eyes were examined for ocular reactions in accordance with the method of Draize at approximately 1, 24, 48 and 72 hours after dosing and on study day 7.
Three of six animals were noted with positive cornea opacity effects (maximum score grade 1), iridal effects (maximum score grade 1), conjunctival redness (maximum score grade 2) and conjunctival chemosis (maximum score grade 2). The other three animals showed no effects throughout the study. All positive effects observed had resolved by day 7. The individual animal mean scores for the 24, 48 and 72 hr time-point indicated that this material would not be classified under EU regulations.
Based on the analogue read across approach, the target substance Solvent Blue 79 is predicted to be non irritating to eyes.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A read across approach was used to an analogue substance; Solvent Blue 98, which has a similar composition/structure.
The skin irritation potential of the analogue material was evaluated in New Zealand White rabbits. There were no irritative effects observed in any of the animals at any time-point. All animals appeared normal throughout the course of the study. The individual animal mean scores for the 24.5, 48 and 72 hr time-point for the intact skin indicated that this material would not be classified under EU regulations.
Based on the analogue read across approach, the target substance Solvent Blue 79 is predicted to be non irritating to skin.
A read across approach was used to an analogue substance; Solvent Blue 98, which has a similar composition/structure.
The primary ocular irritation potential of the analogue material was evaluated in New Zealand White rabbits. One group of six albino rabbits received a single, unwashed exposure. A 0.1- ml dose of the test article was instilled into the lower conjunctival sac of one eye. The eyelids were held together for approximately one second and released. The other eye served as an untreated control. The eyes were examined for ocular reactions in accordance with the method of Draize at approximately 1, 24, 48 and 72 hours after dosing and on study day 7.
Three of six animals were noted with positive cornea opacity effects (maximum score grade 1), iridal effects (maximum score grade 1), conjunctival redness (maximum score grade 2) and conjunctival chemosis (maximum score grade 2). The other three animals showed no effects throughout the study. All positive effects observed had resolved by day 7. The individual animal mean scores for the 24, 48 and 72 hr time-point indicated that this material would not be classified under EU regulations.
Based on the analogue read across approach, the target substance Solvent Blue 79 is predicted to be non irritating to eyes.
Justification for classification or non-classification
Classification criteria not met.
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