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Diss Factsheets
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EC number: 205-293-0 | CAS number: 137-42-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from European Food Safety Authority
- Objective of study:
- absorption
- distribution
- excretion
- metabolism
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- In vivo Absorption, Distribution, Excretionand Metabolism study of 44-( Metam-sodium in mice and rat
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Metam-sodium
- Molecular formula (if other than submission substance): C2H4NNaS2
- Molecular weight (if other than submission substance): 129.1826 g/mole
- Substance type: Organic - Radiolabelling:
- not specified
- Species:
- other: Mice and rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- not specified
- Vehicle:
- not specified
- Details on exposure:
- not specified
- Duration and frequency of treatment / exposure:
- not specified
- Remarks:
- not specified
- No. of animals per sex per dose / concentration:
- not specified
- Control animals:
- not specified
- Positive control reference chemical:
- not specified
- Details on study design:
- not specified
- Details on dosing and sampling:
- not specified
- Statistics:
- not specified
- Preliminary studies:
- not specified
- Type:
- absorption
- Results:
- Oral absorption of metam is rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively).
- Type:
- distribution
- Results:
- Metam is uniformly distributed with slight accumulation in the thyroid in mice and rats
- Type:
- metabolism
- Results:
- The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air.
- Type:
- excretion
- Results:
- Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.
- Details on absorption:
- Oral absorption of metam is rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively).
- Details on distribution in tissues:
- Metam is uniformly distributed with slight accumulation in the thyroid in mice and rats
- Details on excretion:
- Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.
- Metabolites identified:
- yes
- Remarks:
- MITC, CO2, and COS. MITC, CS2
- Details on metabolites:
- The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air. The other significant pathway for metam is the release of CS2, which could be related to the acidic conditions existent in the stomach of the rat (pH=3.8-5) following oral ingestion.
- Conclusions:
- Low bio-accumulation potential based on study results
- Executive summary:
Available data pertaining to the in-vivo Absorption,Distribution, Metabolism and Excretion of the chemical 4-(Metam-sodium suggests absorbed Orally rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively) and uniformly distributed with slight accumulation in the thyroid in mice and rats. The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air. The other significant pathway for metam is the release of CS2, which could be related to the acidic conditions existent in the stomach of the rat (pH=3.8-5) following oral ingestion. Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.Thus, there is low evidence of4-(Metam-sodiumto accumulate in tissues and cause a concern for consumer safety. Also, th use as a pesticide, plant fumigant to control weeds, nematodes, fungi, bacteria and insects (United states environment protaction agecny, 1994). Hence it is concluded that Metam-sodiumis likely to exhibit low bio-accumulation potential based on study results and use.
Reference
Description of key information
There is low evidence of 4-(Metam-sodiumto accumulate in tissues and cause a concern for consumer safety. Also, it use as a pesticide, plant fumigant to control weeds, nematodes, fungi, bacteria and insects (United states environment protaction agecny, 1994). Hence it is concluded that Metam-sodiumis likely to exhibit low bio-accumulation potential based on study results and use.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
Available data pertaining to the in-vivo Absorption,Distribution, Metabolism and Excretion of the chemical 4-(Metam-sodium suggests absorbed Orally rapid and almost complete (85%) based on urinary and expired air excretion (50 and 35%, respectively) and uniformly distributed with slight accumulation in the thyroid in mice and rats. The metabolism of metam is extensive and rapid, suggesting a decomposition of metam into MITC, CO2, and COS. MITC is further conjugated to glutathione and excreted in urine while CO2 and COS are excreted via expired air. The other significant pathway for metam is the release of CS2, which could be related to the acidic conditions existent in the stomach of the rat (pH=3.8-5) following oral ingestion. Excretion is almost complete within 24-48 h after administration, with minor portions excreted up to 168 h after dosing.Thus, there is low evidence of4-(Metam-sodiumto accumulate in tissues and cause a concern for consumer safety. Also, th use as a pesticide, plant fumigant to control weeds, nematodes, fungi, bacteria and insects (United states environment protaction agecny, 1994). Hence it is concluded that Metam-sodiumis likely to exhibit low bio-accumulation potential based on study results and use.
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