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EC number: 219-135-3 | CAS number: 2370-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge (adaptation not specified)
- Details on inoculum:
- - Concentration of sludge: 30 mg/L
- Duration of test (contact time):
- 14 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Details on study design:
- a) Water Temperature: 24 - 26 °C
b) Inoculum: standardized activated sludge, 30 mg/L as suspended solid
c) Exposure Vessel Type: 300 mL culture bottle
d) Number of Replicate: 3 - Parameter:
- other: BOD
- Value:
- 92 - 100
- Sampling time:
- 14 d
- Parameter:
- % degradation (TOC removal)
- Value:
- 86 - 87
- Sampling time:
- 14 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The test substance was degraded 92-100% after 14 days.
- Executive summary:
In a MITI, OECD 301C biodegradation test, the material was found to be readily biodegradable based on 92 -100% degradation after 14 days.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. Non-GLP.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Version / remarks:
- adopted 17 July 1992
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- not specified
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- not specified
- Details on inoculum:
- no data
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 3.3 mg/L
- Based on:
- test mat.
- Initial conc.:
- 2.02 other: mg O2/mg
- Based on:
- ThOD/L
- Initial conc.:
- 1.65 other: mg/L, toxicity control
- Based on:
- test mat.
- Initial conc.:
- 1.83 other: mg O2/mg, toxicity control
- Based on:
- ThOD/L
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST SYSTEM
- Number of culture flasks/concentration: 3 (test substance); 2 (inoculum blank, toxicity control, reference substance)
- Test performed in closed vessels due to significant volatility of test substance: closed bottle test
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes; medium + inoculum
- Abiotic sterile control: no
- Toxicity control: yes; medium + inoculum + test item (1.65 mg/L) + reference substance (2 mg/L)
- Reference substance: medium + inoculum + reference substance (4 mg/L) - Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (O2 consumption)
- Value:
- 1.2
- Sampling time:
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 41.7
- Sampling time:
- 28 d
- Remarks on result:
- other: toxicity control
- Details on results:
- The biodegradation of the test substance remained below 5% (1.1 - 4.3%) throughout the study period of 28 d. The biodegradation in the toxicity control ranged between 41.0 and 42.4%.
- Results with reference substance:
- The reference substance degraded normally under the test conditions (86.1% after 14 d).
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- The ready biodegradation of ETMA was investigated in a study conducted according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test). The biodegradation of the test substance remained below 5% throughout the study period of 28 d (1.1 – 4.3%). No biodegradation was observed under the conditions of the study.
- Executive summary:
The ready biodegradation of ETMA was investigated in a study conducted according to OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test), adopted 17 July 1992 and EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test), over a period of 28 days. The type of inoculum was not specified in the study report. The biodegradation rate was determined by measurement of O2 consumption. Inoculum blank and procedural/functional control with the reference substance sodium benzoate were performed.
The functional control reached the pass level >60% after 14 d. The biodegradation of the test substance remained below 5% throughout the study period of 28 d (1.1 – 4.3%). No biodegradation was observed under the conditions of the present study.
The biodegradation in the toxicity control ranged between 41.0 and 42.4%. According to the criteria of the OECD guideline 301 D, a substance can be assumed to be inhibitory, if less than 25% (based on total ThOD) degradation occurred within 14 days. Thus, ETMA did not inhibit bacterial activity.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- estimated by calculation using EPIWEB version 4.1, BIOWIN (v4.10)
- GLP compliance:
- no
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Based on the prediction of EPIWEB version 4.1, BIOWIN (v4.10) ETMA is considered to be readily biodegradable.
Referenceopen allclose all
biodegradation [%] |
7 d |
14 d |
20 d |
28 d |
test substance |
2.3 |
1.1 |
4.3 |
1.2 |
toxicity control |
42.4 |
41.0 |
42.1 |
41.7 |
reference substance |
84.5 |
86.1 |
83.1 |
84.5 |
BIOWIN (v4.10) Program Results:
==============================
SMILES : O=C(OCCOCC)C(=C)C
CHEM : ETMA
MOL FOR: C8 H14 O3
MOL WT : 158.20
--------------------------- BIOWIN v4.10 Results ----------------------------
Biowin1 (Linear Model Prediction) : Does Not Biodegrade Fast
Biowin2 (Non-Linear Model Prediction): Biodegrades Fast
Biowin3 (Ultimate Biodegradation Timeframe): Weeks
Biowin4 (Primary Biodegradation Timeframe): Days
Biowin5 (MITI Linear Model Prediction) : Biodegrades Fast
Biowin6 (MITI Non-Linear Model Prediction): Biodegrades Fast
Biowin7 (Anaerobic Model Prediction): Biodegrades Fast
Ready Biodegradability Prediction: YES
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin1 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Ester [-C(=O)-O-C] | 0.1742 | 0.1742
Frag | 1 | Aliphatic ether [C-O-C] | -0.3474 | -0.3474
MolWt| * | Molecular Weight Parameter | | -0.0753
Const| * | Equation Constant | | 0.7475
============+============================================+=========+=========
RESULT | Biowin1 (Linear Biodeg Probability) | | 0.4991
============+============================================+=========+=========
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin2 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Ester [-C(=O)-O-C] | 4.0795 | 4.0795
Frag | 1 | Aliphatic ether [C-O-C] | -3.4294 | -3.4294
MolWt| * | Molecular Weight Parameter | | -2.2464
============+============================================+=========+=========
RESULT | Biowin2 (Non-Linear Biodeg Probability) | | 0.8041
============+============================================+=========+=========
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin3 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Ester [-C(=O)-O-C] | 0.1402 | 0.1402
Frag | 1 | Aliphatic ether [C-O-C] | -0.0087 | -0.0087
MolWt| * | Molecular Weight Parameter | | -0.3496
Const| * | Equation Constant | | 3.1992
============+============================================+=========+=========
RESULT | Biowin3 (Survey Model - Ultimate Biodeg) | | 2.9811
============+============================================+=========+=========
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin4 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Ester [-C(=O)-O-C] | 0.2290 | 0.2290
Frag | 1 | Aliphatic ether [C-O-C] | -0.0097 | -0.0097
MolWt| * | Molecular Weight Parameter | | -0.2282
Const| * | Equation Constant | | 3.8477
============+============================================+=========+=========
RESULT | Biowin4 (Survey Model - Primary Biodeg) | | 3.8387
============+============================================+=========+=========
Result Classification: 5.00 -> hours 4.00 -> days 3.00 -> weeks
(Primary & Ultimate) 2.00 -> months 1.00 -> longer
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin5 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Ester [-C(=O)-O-C] | 0.3437 | 0.3437
Frag | 1 | Aliphatic ether [C-O-C] | 0.0015 | 0.0015
Frag | 2 | Methyl [-CH3] | 0.0004 | 0.0008
Frag | 3 | -CH2- [linear] | 0.0494 | 0.1482
Frag | 2 | -C=CH [alkenyl hydrogen] | 0.0062 | 0.0124
MolWt| * | Molecular Weight Parameter | | -0.4706
Const| * | Equation Constant | | 0.7121
============+============================================+=========+=========
RESULT | Biowin5 (MITI Linear Biodeg Probability) | | 0.7482
============+============================================+=========+=========
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin6 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Ester [-C(=O)-O-C] | 2.4462 | 2.4462
Frag | 1 | Aliphatic ether [C-O-C] | -0.1071 | -0.1071
Frag | 2 | Methyl [-CH3] | 0.0194 | 0.0389
Frag | 3 | -CH2- [linear] | 0.4295 | 1.2885
Frag | 2 | -C=CH [alkenyl hydrogen] | 0.0285 | 0.0570
MolWt| * | Molecular Weight Parameter | | -4.5670
============+============================================+=========+=========
RESULT |Biowin6 (MITI Non-Linear Biodeg Probability)| | 0.8432
============+============================================+=========+=========
A Probability Greater Than or Equal to 0.5 indicates --> Readily Degradable
A Probability Less Than 0.5 indicates --> NOT Readily Degradable
------+-----+--------------------------------------------+---------+---------
TYPE | NUM | Biowin7 FRAGMENT DESCRIPTION | COEFF | VALUE
------+-----+--------------------------------------------+---------+---------
Frag | 1 | Ester [-C(=O)-O-C] | 0.1719 | 0.1719
Frag | 1 | Aliphatic ether [C-O-C] | -0.2573 | -0.2573
Frag | 2 | Methyl [-CH3] | -0.0796 | -0.1591
Frag | 3 | -CH2- [linear] | 0.0260 | 0.0780
Frag | 2 | -C=CH [alkenyl hydrogen] | -0.0735 | -0.1470
Const| * | Equation Constant | | 0.8361
============+============================================+=========+=========
RESULT | Biowin7 (Anaerobic Linear Biodeg Prob) | | 0.5225
============+============================================+=========+=========
A Probability Greater Than or Equal to 0.5 indicates --> Biodegrades Fast
A Probability Less Than 0.5 indicates --> Does NOT Biodegrade Fast
Ready Biodegradability Prediction: (YES or NO)
----------------------------------------------
Criteria for the YES or NO prediction: If the Biowin3 (ultimate survey model) result is "weeks" or faster (i.e. "days", "days to weeks", or "weeks" AND the Biowin5 (MITI linear model) probability is >= 0.5, then the prediction is YES (readily biodegradable). If this condition is not satisfied, the prediction is NO (not readily biodegradable). This method is based on application of Bayesian analysis to ready biodegradation data (see Help). Biowin5 and 6 also predict ready biodegradability, but for degradation in the OECD301C test only; using data from the Chemicals
Evaluation and Research Institute Japan (CERIJ) database.
Description of key information
readily biodegradable; category interpolation, EPIWEB prediction
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
No reliable experimental data are available for the biodegradation of ETMA. The available study is considered as not reliable due to insufficient documentation (Klimisch score 3): No biodegradation was observed under the conditions of this study.
Reliable studies are available for other category members, e.g. HEMA: In a MITI, OECD 301C biodegradation test, HEMA was found to be readily biodegradable based on 92 -100% degradation after 14 days.
Thus, by interpolation within the category and based upon EPIWEB predictions (EPIWEB version 4.1, BIOWIN (v4.10)) and structural considerations ETMA is considered readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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