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EC number: 232-237-2 | CAS number: 7791-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation test: The test material showed irritative properties
Skin corrosion test: The test material showed a corrosion potential
Bovine corneal opacity and permeability test (BCOP): no prediction can be made
EpiOcular eye irritation test: irritating
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
- GLP compliance:
- yes (incl. QA statement)
- Test system:
- human skin model
- Source species:
- human
- Details on test system:
- The EpiDermTM model consists of normal, human-derived epidermal keratinocytes which have been cultured to form a multi layered, highly differentiated model of the human
epidermis. It consists of organized basal, spinous and granular layers, and a multi-layered stratum corneum containing intercellular lamellar lipid layers arranged in patterns analogous to those found in vivo. The EpiDermTM tissues (surface 0.6 cm²) are cultured on specially prepared cell culture inserts (MILLICELLs, 10 mm ∅) and are commercially available as kits (EpiDerm™ 200), containing 24 tissues on shipping agarose.
TEMPERATURE USED FOR TEST SYSTEM
- Temperature used during treatment / exposure: room temperature (25 min), 37°C (35 min)
- Temperature of post-treatment incubation (if applicable): 37°C
DYE BINDING METHOD
- Dye used in the dye-binding assay: MTT
- Wavelength: 570 nm - Control samples:
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount/concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 25 ul
VEHICLE
- Amount(s) applied (volume or weight with unit): 25 ul
NEGATIVE CONTROL
- Amount(s) applied (volume or weight): 30 ul
POSITIVE CONTROL
- Amount(s) applied (volume or weight): 30 ul - Duration of treatment / exposure:
- 1 hour
- Duration of post-treatment incubation (if applicable):
- 42 hours
- Number of replicates:
- 3
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- mean of 3 tissues
- Value:
- 3
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- GLP compliance:
- yes (incl. QA statement)
- Test system:
- human skin model
- Source species:
- human
- Details on test system:
- THREE-DIMENSIONAL HUMAN EPIDERMIS MODEL
The EpiDermTM model consists of normal, human-derived epidermal keratinocytes which have been cultured to form a multi layered, highly differentiated model of the human epidermis. It consists of organized basal, spinous and granular layers, and a multi-layered stratum corneum containing intercellular lamellar lipid layers arranged in patterns analogous to those found in vivo. The EpiDermTM tissues (surface 0.6 cm²) are cultured on specially prepared cell culture inserts (MILLICELLs, 10 mm ∅) and are commercially available as kits (EpiDerm™ 200), containing 24 tissues on shipping agarose.
From the day of arrival in the laboratory, tissues were kept in the refrigerator. At least 1 hour but not more than 1.5 hours before test-substance application, tissues were transferred to 6-well plates with 0.9 mL assay medium and preconditioned in the incubator at 37°C. The preincubation medium was replaced with fresh medium immediately before application. Two tissues per exposure time (3 minutes at room temperature or 1 hour in the incubator, as a rule) and test group (test material, negative control and positive control; 12 tissues per test) were used.
25 μL de-ionized water was applied first. Thereafter, a bulk volume of ca. 25 μL of the solid ground test material was applied with a sharp spoon and homogeneously distributed with the water.
Control tissues were concurrently treated with 50 μL of de-ionized water (NC) or with 50 μL of 8 N potassium hydroxide (PC).
The tissues were washed with PBS to remove residual test material 3 minutes or 1 hour after start of the application treatment.
Rinsed tissues were kept in 24-well plates (holding plates) at room temperature on assay medium until all tissues per application time were dosed and rinsed. The assay medium was then replaced by MTT solution and tissues were incubated for 3 hours. After incubation, the tissues were washed with PBS to stop the MTT-incubation. The formazan that was metabolically produced by the tissues was extracted by incubation of the tissues in isopropanol. The optical density at a wavelength of 570 nm (OD570) of the extracts was determined spectrophotometrically. Blank values were established of 4 microtiter wells filled with isopropanol for each microtiter plate.
DATA EVALUATION:
Corrosive potential of the test materials is predicted from the mean relative tissue viabilities obtained after 3 min treatment compared to the negative control tissues concurrently treated with de-ionized water. A chemical is considered as "corrosive", if the mean relative tissue viability after 3 min treatment with a test material is decreased below 50%. In addition, those materials with a viability of ≥ 50% after 3 min treatment are considered as "corrosive" if the mean relative tissue viability after 1 hour treatment with a test material is decreased below 15%. - Control samples:
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount/concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 25 ul of solid ground material
VEHICLE
- Amount(s) applied (volume or weight with unit): 25 ul
NEGATIVE CONTROL
- Amount(s) applied (volume or weight): 50 ul
POSITIVE CONTROL
- Amount(s) applied (volume or weight): 50 ul - Duration of treatment / exposure:
- 3 min or 1 hour
- Duration of post-treatment incubation (if applicable):
- 3 hours
- Number of replicates:
- 2
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 3 min exposure
- Value:
- 86.5
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 1 hour exposure, experiment 1
- Value:
- 21.1
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Remarks on result:
- other:
- Remarks:
- variations in results, therefore experiment was repeated
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- 1 hour exposure, experiment 2
- Value:
- 7.4
- Vehicle controls validity:
- valid
- Negative controls validity:
- not valid
- Positive controls validity:
- valid
Referenceopen allclose all
Test substance identification |
|
Tissue 1 |
Tissue 2 |
Tissue 3 |
Mean |
SD |
CV [%] |
NC |
Mean OD570 |
1.995 |
2.178 |
2.097 |
2.090 |
|
|
Viability [% of NC] |
95.5 |
104.2 |
100.3 |
100.0 |
4.4 |
4.4 |
|
Test substance |
Mean OD570 |
0.057 |
0.061 |
0.068 |
0.062 |
|
|
Viability [% of NC] |
2.7 |
2.9 |
3.2 |
3.0 |
0.3 |
8.9 |
|
PC |
Mean OD570 |
0.052 |
0.051 |
0.049 |
0.051 |
|
|
Viability [% of NC] |
2.5 |
2.5 |
2.4 |
2.4 |
0.1 |
2.6 |
NC, negative control
PC, positive control
Exposure period: 3 min |
||||||
Test substance identification |
|
Tissue 1 |
Tissue 2 |
Mean |
SD |
CV [%] |
NC |
Mean OD570 |
1.986 |
2.031 |
2.008 |
|
|
Viability [% of NC] |
98.9 |
101.1 |
100 |
1.6 |
1.6 |
|
Test substance |
Mean OD570 |
1.825 |
1.651 |
1.738 |
|
|
Viability [% of NC] |
90.0 |
82.2 |
86.5 |
6.1 |
7.1 |
|
PC |
Mean OD570 |
0.237 |
0.251 |
0.244 |
|
|
Viability [% of NC] |
11.8 |
12.5 |
12.1 |
0.5 |
4.1 |
Exposure period: 1 hour (Experiment 1) |
||||||
Test substance identification |
|
Tissue 1 |
Tissue 2 |
Mean |
SD |
CV [%] |
NC |
Mean OD570 |
2.195 |
1.981 |
2.088 |
|
|
Viability [% of NC] |
105.1 |
94.9 |
100.0 |
7.2 |
7.2 |
|
Test substance |
Mean OD570 |
0.599 |
0.284 |
0.442 |
|
|
Viability [% of NC] |
28.7 |
13.6 |
21.1 |
10.7 |
50.5 |
|
PC |
Mean OD570 |
0.148 |
0.159 |
0.154 |
|
|
Viability [% of NC] |
7.1 |
7.6 |
7.4 |
0.4 |
5.1 |
Exposure period: 1 hour (Experiment 2) |
||||||
Test substance identification |
|
Tissue 1 |
Tissue 2 |
Mean |
SD |
CV [%] |
NC |
Mean OD570 |
1.814 |
1.984 |
1.899 |
|
|
Viability [% of NC] |
95.5 |
104.5 |
100.0 |
6.3 |
6.3 |
|
Test substance |
Mean OD570 |
0.136 |
0.146 |
0.141 |
|
|
Viability [% of NC] |
7.1 |
7.7 |
7.4 |
0.4 |
5.3 |
|
PC |
Mean OD570 |
0.078 |
0.087 |
0.082 |
|
|
Viability [% of NC] |
4.1 |
4.6 |
4.3 |
0.3 |
7.3 |
NC, negative control
PC, positive control
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 437 (Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- cattle
- Details on test animals or tissues and environmental conditions:
- SOURCE OF COLLECTED EYES
- Source: Schlachthof Mannheim, Schlachthofstr. 21, 68165 Mannheim, Germany
- Characteristics of donor animals (e.g. age, sex, weight): age minimum 12 months, maximum 60 months
- indication of any existing defects or lesions in ocular tissue samples: Corneas free of defects (opacity, scratches, pigmentation etc.) were dissected with a 2 to 3 mm rim of sclera. Isolated corneas were mounted in cornea holders that consists of anterior and posterior chambers. Both chambers were filled to excess with pre-warmed Eagle’s MEM (without phenol red) and then equilibrated in a vertical position at about 32 °C for at least 1 hour. After the equilibration period the medium in both chambers was replaced with fresh prewarmed medium and initial corneal opacity readings were taken for each cornea with an opacitometer. Any corneas that showed macroscopic tissue damage or opacity were discarded. - Vehicle:
- water
- Remarks:
- deionized water
- Controls:
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 750 μL 20% (w/v) test-substance preparation (non-surfactant) was applied using a pipette.
- Concentration (if solution): 20% (w/v)
- Duration of treatment / exposure:
- The corneas were incubated in a horizontal position at about 32 °C for approximately 4 hours (non-surfactant solids). The test substance, NC and PC were then removed from the anterior chamber using a syringe and the epithelium was washed at least 3 times with Eagle’s MEM (containing phenol red) and once with Eagle’s MEM (without phenol red). Both chambers were then refilled with fresh Eagle’s MEM (without phenol red).
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- SELECTION AND PREPARATION OF CORNEAS
see above
QUALITY CHECK OF THE ISOLATED CORNEAS
see above
NUMBER OF REPLICATES
3
NEGATIVE CONTROL USED
see above
SOLVENT CONTROL USED (if applicable)
see above
POSITIVE CONTROL USED
see above
APPLICATION DOSE AND EXPOSURE TIME
see above
TREATMENT METHOD: [closed chamber / open chamber]
see above
REMOVAL OF TEST SUBSTANCE
- Number of washing steps after exposure period: at least 3 times
METHODS FOR MEASURED ENDPOINTS:
- Corneal opacity: Before measurement, each cornea was observed visually and observations were recorded. Final corneal opacity readings were taken for each cornea with an opacitometer.
- Corneal permeability: passage of sodium fluorescein dye measured with the aid of UV/VIS spectrophotometry
SCORING SYSTEM AND DECISION CRITERIA: In Vitro Irritancy Score (IVIS)
In addition to the scoring system stated in the guideline, a borderline“-evaluation (IVIS 3.0 ± 1.5 and 55.0 ± 10.0) was determined statistically using historic BASF data. This takes the test facility specific variance of the test method into account. This evaluation is an amendment to the evaluation provided in OECD Guideline 437. - Irritation parameter:
- in vitro irritation score
- Value:
- 47.1
- Vehicle controls validity:
- valid
- Negative controls validity:
- not applicable
- Positive controls validity:
- valid
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- human
- Details on test animals or tissues and environmental conditions:
- - Justification of the test method and considerations regarding applicability:
The objective of this in vitro test is to assess the eye irritation potential of the test substance by using the reconstructed human ocular tissue model EpiOcularTM. The test is based on the experience that irritant chemicals produce cytotoxicity in human reconstructed cornea after a short term topical exposure. The test is designed to predict an eye irritation potential of a chemical by using the three-dimensional, human cornea model EpiOcularTM. After application of the test material to the surface of the EpiOcularTM tissue, the induced cytotoxicity (= loss of viability) is measured by a colorimetric assay. Cytotoxicity is expressed as the reduction of mitochondrial dehydrogenase activity. The mitochondrial dehydrogenase reduces the yellow colored water-soluble 3-[4.5-dimethylthiazol-2-yl]-2.5-diphenyltetrazolium bromide (MTT) to the insoluble blue colored formazan. After isopropanol extraction of the formazan from the tissues, the optical density of the extract is spectrophotometrically determined. The optical density of the extracts of the tissues treated with the test substance is compared to values from negative control tissues and expressed as relative tissue viability.
- Description of the cell system used, incl. certificate of authenticity and the mycoplasma status of the cell live
The EpiOcularTM model (OCL-200) is a three-dimensional non-keratinized tissue construct composed of normal human derived epidermal keratinocytes used to model the human corneal epithelium. The EpiOcularTM tissues (surface 0.6 cm²) are cultured on cell culture inserts (MILLICELLs, 10 mm ∅) and are commercially available as kits (EpiOcular™ 200), containing 24 tissues on shipping agarose.
Tissue model: OCL-200
Tissue Lot Number: 23724 (Certificate of Analysis see appendix)
Supplier: MatTek In Vitro Life Science Laboratories, Bratislava, Slovakia - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 ul - Duration of treatment / exposure:
- After application, the tissues were placed into the incubator until the total exposure time of
6 hours was completed. - Duration of post- treatment incubation (in vitro):
- 18 hours
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- - Details of the test procedure used:
1. Direct MTT reduction
To assess the ability of the test material to directly reduce MTT a pretest (experimental
conduct in accordance with GLP but without a GLP status) was performed. The test
substance was added to 0.9 mL of the MTT solution. The mixture was incubated in the dark
at about 37 °C for 3 hours. A negative control (de-ionized water) was tested concurrently. If
the MTT solution color or, in case of water-insoluble test substances the border to the waterphase,
turned blue / purple, the test substance was presumed to directly reduce MTT.
2. Pre-incubation of the tissues
On the day of arrival in the laboratory, the tissues were transferred to sterile 6-well plates with
1 mL assay medium and preconditioned in the incubator at 37°C. After 1 hour the preincubation
medium was replaced with fresh medium and preconditioning continued in the
incubator at standard culture conditions for 16 – 24 hours.
3. Pre-treatment of the tissues
After the pre-incubation, the tissues were pre-treated with 20 μL of PBS in order to wet the
tissue surface. The tissues were incubated at standard culture conditions for 30 minutes.
4. Application of the test substance
Using a sharp spoon, a bulk volume of ca. 50 μL of the test material was applied covering the
whole tissue surface.
Control tissues were concurrently applied with 50 μL of sterile de-ionized water (NC) or with
50 μL of methyl acetate (PC).
After application, the tissues were placed into the incubator until the total exposure time of
6 hours was completed.
5. Removal of the test substance and postincubation period
To remove the test substance, the tissues were washed with sterile PBS. For this purpose
the tissues were immersed and swiveled three times in each of three beakers filled with PBS.
Washed tissues were immediately immersed into 12-well plates, pre-filled with 5 mL/well prewarmed
medium (post-soak immersion) in order to remove residual test substance.
After 25 minutes of post-soak immersion, each tissue was dried on absorbent paper and
transferred to fresh 6-well plates filled with 1 mL/well pre-warmed medium.
Subsequently, the tissues were incubated at standard culture conditions for 18 hours
(postincubation period).
6. MTT incubation
After the post-incubation period, the assay medium was replaced by 0.3 mL MTT solution
and the tissues were incubated in the incubator for 3 hours.
After incubation, the tissues were washed with PBS to stop the MTT-incubation.
The formazan that was metabolically produced by the tissues was extracted by incubation of
the tissues in isopropanol at room temperature overnight or for at least 2 hours on a plate
shaker. The optical density at a wavelength of 570 nm (OD570) of the extracts was
determined spectrophotometrically. Blank values were established of 4 microtiter wells filled
with isopropanol for each microtiter plate.
- RhCE tissue construct used, including batch number: OCL-200, batch 23724
- Duration and temperature of exposure, post-exposure immersion and post-exposure incubation periods (where applicable)
- Number of tissue replicates used per test chemical and controls (positive control, negative control, NSMTT, NSCliving and NSCkilled, if applicable). 2
- Positive and negative control means and acceptance ranges based on historical data
The mean OD and viability value of the PC of the present EpiOcular Test were slightly below the historical range. However, as all other quality criteria of the test were met, this deviation is not considered to have any influence on the validity of the data. - Irritation parameter:
- other: tissue viability
- Run / experiment:
- mean
- Value:
- 2.2
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- valid
- Positive controls validity:
- other: The mean OD and viability value of the PC of the present Test were slightly below the historical range. However, as all other quality criteria of the test were met, this deviation is not considered to have any influence on the validity of the data.
Referenceopen allclose all
Test substance identification |
Cornea No. |
Opacity per cornea |
Permeability per cornea |
IVIS |
||
Per cornea |
Per group |
|||||
Mean |
SD |
|||||
Test substance |
10 |
36.4 |
0.504 |
44.0 |
47.1 |
3.1 |
11 |
35.6 |
0.760 |
47.0 |
|||
12 |
40.4 |
0.652 |
50.2 |
|||
NC |
1 |
14.9 |
0.000 |
14.9 |
10.5 |
5.3 |
2 |
4.6 |
0.001 |
4.6 |
|||
3 |
11.8 |
0.004 |
11.9 |
|||
PC |
4 |
74.7 |
4.025 |
135.0 |
130.8 |
3.7 |
5 |
78.0 |
3.336 |
128.0 |
|||
6 |
86.1 |
2.878 |
129.2 |
NC, negative control
PC, positive control
Test substance identification |
|
Tissue 1 |
Tissue 2 |
Mean |
Inter-tissue variability [%] |
NC |
Mean OD570 |
1.594 |
1.557 |
1.575 |
|
|
Viability [% of NC] |
101.2 |
98.8 |
100.0 |
2.3 |
Test substance |
Mean OD570 |
0.035 |
0.035 |
0.035 |
|
|
Viability [% of NC] |
2.2 |
2.2 |
2.2 |
0.0 |
PC |
Mean OD570 |
0.169 |
0.172 |
0.170 |
|
|
Viability [% of NC] |
10.7 |
10.9 |
10.8 |
0.2 |
NC, negative control
PC, positive control
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the data available and according to the criteria for classification and labelling laid down in Regulation (EC) 1272/2008 (CLP), the test substance can be considered corrosive. Therefore, classification with H314 ("causes severe skin burns and eye damage") is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.