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EC number: 228-762-1 | CAS number: 6358-09-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Hydrolysis of 2-amino-6-chloro-4-nitrophenol was lower than 10 % for all the three pH values (pH 4, 7 and 9) tested after 5 days at 50°C. As hydrolysis lower than 10 % was observed after 5 days during a preliminary test, so the test item should be regarded as hydrolytically stable.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1 yr
- at the temperature of:
- 50 °C
Additional information
Hydrolysis of 2-amino-6-chloro-4-nitrophenol was determined under GLP and following OECD 111 and EU C.7 method.
A preliminary hydrolysis test was conducted with buffer solutions of pH 4.0, 7.0 and 9.0 at temperature of 50°C. Two sample solutions were prepared for each pH buffer by adding 1.00 mL of a 20 mg/mL test substance solution in methanol (HPLC grade) into a 100 mL buffer solution.
Samples were collected at 0 hour (test start), after 2.4 hours and 5 days (after placing the sample solutions into the water thermostatic bath at 50°C). The active ingredient content of the solutions was analyzed by UV/Visible detector, with internal standard.
Hydrolysis of lower than 10 % was observed for all the three pH conditions tested after 5 days at 50°C. So the test itel is considered as hydrolytically stable.
As per recommendations of the OJEC C.7 method, if the preliminary test indicates that 50% or more of the test substance has been hydrolyzed in 2.4 hours at 50°C or less than 10% has been hydrolyzed after five days at each of the three pH values (4, 7 and 9), no further testing is necessary. Therefore, no definitive test was performed.
This hydrolysis test is classified as acceptable, and satisfies the guideline requirements of the OECD 111 guideline.
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