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Diss Factsheets
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EC number: 232-030-7 | CAS number: 7783-84-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- data is from safety assessment reports
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Ferric phosphate- Toxicological evaluation
- Author:
- European Food Safety Authority (EFSA)
- Year:
- 2 013
- Bibliographic source:
- Ferric phosphate - RAR - Vol. 3, 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- To assess the extent of irritation or corrosion caused by Test chemical to rabbit skin
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Iron orthophosphate
- EC Number:
- 233-149-7
- EC Name:
- Iron orthophosphate
- Cas Number:
- 10045-86-0
- Molecular formula:
- Fe.H3O4P
- IUPAC Name:
- Ferric phosphate
- Test material form:
- solid: crystalline
- Details on test material:
- Name of the test compound: Ferric orthophosphate
Molecular formula: FePO4
Molecular weight: 154 g/mo/l
Substance type: Inorganic
Physical State: Solid
Lot/Batch no.: 105668
Purity: Minimum 24.8 % Fe
Stability of test compound: Stable under recommended storage conditions (room temp. in the dark)
Constituent 1
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- other: Milli-U water used to moisten the substance to ensure good skin contact.
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 g applied undiluted. Milli-U water used to moisten the substance to ensure good skin contact.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 male New Zealand White rabbits
- Details on study design:
- Details on study design
TEST SITE
- Area of exposure: clipped dorsum
- % coverage: no data available
- Type of wrap if used: no data available
SCORING SYSTEM: no data available
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 0
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
No irritation was observed at any of the treated dermal sites on three rabbits exposed for 4 hours to test chemical. There was no evidence of a corrosive reaction and no indications of dermal staining by the test substance. No mortalities occurred and there were no signs of systemic toxicity recorded.
Applicant's summary and conclusion
- Interpretation of results:
- other: not irritating
- Conclusions:
- No irritation was observed at any of the treated dermal sites on three rabbits exposed for 4 hours to the test chemical. There was no evidence of a corrosive reaction and no indications of dermal staining by the
test substance. No mortalities occurred and there were no signs of systemic toxicity recorded.
Based on these observations the test chemical can be considered to be not irritating to rabbit skin. - Executive summary:
A study was performed to assess the extent of irritation or corrosion caused by test chemical to rabbit skin. The study was performed according toOECD 404 andEC Commission Directive 92/69/EEC, Method B4, Acute Toxicity – Skin irritation.0.5 g of test chemical was applied undiluted to the clipped dorsum skin of 3 male New Zealand White rabbits under semi-occlusive conditions for 4 hours. Milli-U water used to moisten the substance to ensure good skin contact. Dermal observations were made for up to 72 hours.
No irritation was observed at any of the treated dermal sites on three rabbits exposed for 4 hours to test chemical. There was no evidence of a corrosive reaction and no indications of dermal staining by the test substance. No mortalities occurred and there were no signs of systemic toxicity recorded.Based on these observations the test chemical can be considered to be not irritating to rabbit skin.
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