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EC number: 232-122-7 | CAS number: 7787-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Higher doses tested. No tables with individual data included.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bismuth chloride oxide
- EC Number:
- 232-122-7
- EC Name:
- Bismuth chloride oxide
- Cas Number:
- 7787-59-9
- Molecular formula:
- BiClO
- IUPAC Name:
- chlorobismuthanone
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- The test substance was diluted to a formulation of 50% in water.
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Females nulliparous and non-pregnant: Yes
- Weight at study initiation: 190 to 236 g (males); 190 to 225 g (females)
- Fasting period before study: Yes, over night prior dosing
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 1000, 1590, 2510, 3980, 6310, 10000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Mortality and clinical signs at one, four, and 24 hours and once daily thereafter for a total of 14 days.
- Necropsy of survivors performed: Yes, on all animals which died during the study and on those sacrificed (chloroform overdose) at termination
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 1590 mg/kg bw: One male died on day 8
10000 mg/kg bw: One female appeared depressed and hunched at 24 hours, and subsequently died - Clinical signs:
- other: 1000 mg/kg bw: One male showed wheezing from day 5 to termination
- Gross pathology:
- The male rat that died during the study (1590 mg/kg bw) demonstrated dark red areas on all lobes of the lungs. The death of one female rat during the study (10,000 mg/kg bw) was attributed to accidental puncture during gastric intubation.
Any other information on results incl. tables
In the guideline comparable but non-GLP compliant acute oral toxicity test, the test substance was tested for acute oral toxicity with the following doses 1000, 1590, 2510, 3980, 6310 and 10000 mg/kg bw for male and female rats. For each dose and sex 5 animals were used. The test substance (a fomulation of 50%) was administrated undiluted. The animals were observed for a period of 14 days. One male rat died at the 1590 mg/kg level and one female rat died at the 10000 mg/kg level. The death at the higher dose was attributed to accidental puncture during gastric intubation.
In the present acute oral toxicity study an LD50 cut-off value of > 10000 mg/kg bw was found.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/ EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- CLP: not classified
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