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Diss Factsheets
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EC number: 201-969-4 | CAS number: 90-15-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
Materials and methods
- Principles of method if other than guideline:
- Method of Draize and associates was used (Draize et al, J. Pharmacol. Exp. Therap., 82: 377 (1944)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-naphthol
- EC Number:
- 201-969-4
- EC Name:
- 1-naphthol
- Cas Number:
- 90-15-3
- Molecular formula:
- C10H8O
- IUPAC Name:
- naphthalen-1-ol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- The material was either in commercial production or have been evaluated for commerical potential.
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Animals weighed 2.5 to 3.5 kg.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The fur is removed from the entire trunk by clipping, and the dose is retained beneath an impervious plastic film. Dosages greater than 20ml/kg cannot be applied in contact with the skin.
- Duration of exposure:
- Animals are immobolized during the 24-hour contact period, after which the film is removed and the rabbits are caged for subsequent 14-day observation period.
- Doses:
- 0.33 to 2.35
- No. of animals per sex per dose:
- four
- Control animals:
- not required
- Statistics:
- The LD50 and its fidutial range are estimated by the method of Thompson (Thompson WR: Use of moving Averages and Interpolation to Estimate Median effective dose. Bacteriol. Rev. 11: 115, 1947) using the Tables of Weil (Weil, GS: Tables for convenient calculation of Median-effective Dose (LD50 or ED50) and Instructions in their use. Biometrics 8: 249, 1952). The (dose) figures in parntheses show limits of +/- 1.96 standard deviations
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 880 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- Not described
- Clinical signs:
- other: Not described
- Gross pathology:
- Not mentioned
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Note: substance has a harmonized classification as Cat 4
- Conclusions:
- The LD50 was 880 mg/kg in NewZealand male albino rabbits in a 24 hour exposure (occlusive) based on acceptable scientific methods (Draize method for experimental procedures and Thompson's method for LD50 calculations).
- Executive summary:
LD50 was calculated to be 880 mg/kg in NewZealand male albino rabbits exposed to 1 -naphthol for 24 hours (occlusive), follwed by a 14-day observation period. Acceptable scientific methods (Draize method for experimental procedures and Thompson's method for LD50 calculations) were used.
Under the conditions of this study, based on the results, this substance is classified as Acute toxicity - dermal, Category 3 according to the UN GHS criteria.
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