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EC number: 279-506-0 | CAS number: 80584-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-09-06 - 1982-09-17
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Environmental Protection Agency (EPA) Paragraph 163. 81-5 "Primary eye irritation study". Federal Register, Vol. 43 No. 163, August 22, 1978
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- 6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:3)
- EC Number:
- 279-506-0
- EC Name:
- 6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:3)
- Cas Number:
- 80584-92-5
- Molecular formula:
- C21H36N6O6.3C6H15NO3
- IUPAC Name:
- 6,6',6''-(1,3,5-triazine-2,4,6-triyltriimino)trihexanoic acid, compound with 2,2',2''-nitrilotriethanol (1:3)
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Kleintierfarm Madoerin AG, 4414 Fuellinsdorf, Switzerland
- Weight at study initiation: 2-3 kg
- Housing: individually in metal cages
- Diet: ad libitum (Rabbit food, NAFAG, No. 814 Tox, NAFAG AG, Gossau, Switzerland)
- Water: ad libitum
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3
- Humidity (%): 55±15
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Adjacent eye served as a control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL - Duration of treatment / exposure:
- In 3 of 6 rabbits approx. 30 sec after the treatment the treated eye was rinsed. The other three rabbits stayed treated until the end of the observation period.
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: 3 out of 6 rabbits were rinsed with 10 mL physiological saline.
- Time after start of exposure: 30 seconds
SCORING SYSTEM: Draize scale
TOOL USED TO ASSESS SCORE: hand-slit lamp
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Eye was rinsed.
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: Eye was rinsed.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.66
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was rinsed.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was rinsed.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.66
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was rinsed.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was not rinsed.
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was rinsed.
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: Eye was rinsed.
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- other: 24, 48 , 72 hours
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: Eye was rinsed.
- Irritant / corrosive response data:
- Minimal irritation was observed in the unrinsed eye.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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