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EC number: 231-327-9 | CAS number: 7493-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin corrosion: Substance is not corrosive as it is also not irritating.
Skin irritation: not irritating (read-across from Hyacinth body tested in OECD TG 404)
Eye irritation: not irritating (read-across from Hyacinth body tested in OECD TG 405)
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- The skin irritation information of this source substance is used for read across to Hyacinth body #3.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- exposure period was 24 h instead of 4 h, observation time points were 0 and 48 h after patch removal instead of 24, 48 and 72 h.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- albino
- Details on test animals or test system and environmental conditions:
- No details provided.
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Remarks:
- electric clipper, avoiding abrasions
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml testing material
- Duration of treatment / exposure:
- 24 hours
- Observation period:
- 48 hours after patch removal
- Number of animals:
- 12 animals - 6 with intact skin and 6 with abraded skin (results for abraded skin are disregarded in this study record).
- Details on study design:
- TEST SITE:
- Area of exposure: 1x1 inch
- Type of wrap if used: surgical patch, fixed to application site with adhesive tape and entire trunk of rabbits is wrapped with impervious material.
OBSERVATION TIME POINTS:
After 24 hours (directly after exposure) and after 72 hours (48 hours after patch removal).
SCORING SYSTEM:
Method of calculation: Draize (J. Pharmacol. 82 (1944) 377-390). - Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 1, 2 and 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 4 and 6
- Time point:
- 24/48/72 h
- Score:
- 1
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- score of animal number 5
- Time point:
- 24/48/72 h
- Score:
- 2
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- scores of animal number 1, 2, 3, 4 and 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- score of animal number 5
- Time point:
- 24/48/72 h
- Score:
- 1
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- score of animal number 3
- Time point:
- other: 0 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 1 and 2
- Time point:
- other: 0 h
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 4 and 6
- Time point:
- other: 0 h
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- score of animal number 5
- Time point:
- other: 0 h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- scores of animal number 1, 2 and 3
- Time point:
- other: 0 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- scores of animal number 4, 5 and 6
- Time point:
- other: 0 h
- Score:
- 1
- Irritant / corrosive response data:
- The test substance was found to induce some skin irritation effects. After 24 hours exposure very slight to moderate erythema and very slight edema was observed. Dermal effects observed 48 hours after patch removal were very slight or well-defined erythema, slight scaliness and very slight edema.
- Interpretation of results:
- other: not skin irritating
- Remarks:
- Based on CLP criteria (EC 1272/2008 and its updates)
- Conclusions:
- Hyacinth body is not an irritant to skin, according to OECD 404.
- Executive summary:
The skin irritation potential of Hyacinth body was tested in vivo using 12 New Zealand white rabbits (6 with intact skin and 6 with abraded skin). Study was performed similar to OECD 404 with some deviations on exposure time and observation period and therefore a Klimisch 2 rating was assigned. The test material was applied on the skin under a surgical patch. After an exposure period of 24 hours the patches were removed. Only testing results of 6 animals with intact skin are considered useful for evaluation of skin irritation. The animals were observed only at 48 hours after patch removal and no observations were done at time points of 24 and 72 hours. Effects observed directly upon patch removal were limited. Regarding erythema, 1 animal scored 3, 2 animals scored 2, 2 animals scored 1 and 1 animal scored 0, and regarding edema, 3 animals scored 1 and 3 animals scored 0. The dermal effects observed at 48 hours after patch removal were decreased to none to moderate erythema (1 animal scored 2, 2 animals scored 1 and 3 animals scored 0) and none to slight edema (1 animal scored 1 and 5 animals scored 0). Directly after patch removal only the erythema score for one animal was above the classification threshold (score 3). Although the study was not continued until the complete disappearance of the effects, the effects decreased largely within the 48 hours after patch removal. Given the longer exposure period of 24 instead of 4 hours and the test results obtained, it can be concluded that Hyacinth body is not an irritant to skin.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information derived from analogue
- Justification for type of information:
- The read across justification is presented in the Irritation / corrosion Endpoint summary. The accompanying files are also attached there.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 1, 2 and 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 4 and 6
- Time point:
- 24/48/72 h
- Score:
- 1
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- score of animal number 5
- Time point:
- 24/48/72 h
- Score:
- 2
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- scores of animal number 1, 2 and 3
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- score of animal number 5
- Time point:
- 24/48/72 h
- Score:
- 1
- Remarks on result:
- other:
- Remarks:
- 24 hours and 72 hours timepoints were not scored
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- score of animal number 3
- Time point:
- other: 0 h
- Score:
- 0
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 1 and 2
- Time point:
- other: 0 h
- Score:
- 1
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- scores of animal number 4 and 6
- Time point:
- other: 0 h
- Score:
- 2
- Irritation parameter:
- erythema score
- Basis:
- other:
- Remarks:
- score of animal number 5
- Time point:
- other: 0 h
- Score:
- 3
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- scores of animal number 1, 2 and 3
- Time point:
- other: 0 h
- Score:
- 0
- Irritation parameter:
- edema score
- Basis:
- other:
- Remarks:
- scores of animal number 4, 5 and 6
- Time point:
- other: 0 h
- Score:
- 1
- Irritant / corrosive response data:
- The test substance was found to induce some skin irritation effects. After 24 hours exposure very slight to moderate erythema and very slight edema was observed. Dermal effects observed 48 hours after patch removal were very slight or well-defined erythema, slight scaliness and very slight edema.
- Interpretation of results:
- other: not skin irritating
- Remarks:
- Based on CLP criteria (EC 1272/2008 and its updates)
- Conclusions:
- Skin irritation: not irritating (read-across from Hyacinth body tested in OECD TG 404).
Referenceopen allclose all
To be able to derive a CLP classification from skin irritation test results, normally the 24, 48 and 72 hours timepoints (after patch removal) for erythema and edema are used. In this study only the 48 hours timepoint is available for evaluation. As supporting evidence the reading directly after removal of the patch is available (0 hours timepoint) and can be considered the worst-case effect. Based on the available eythema and edema scores and the longer exposure period (24 instead of 4 hours), it is concluded that interpretation for CLP purposes is possible with the current test.
To be able to derive a CLP classification from skin irritation test results, normally the 24, 48 and 72 hours timepoints (after patch removal) for erythema and edema are used. In this study only the 48 hours timepoint is available for evaluation. As supporting evidence the reading directly after removal of the patch is available (0 hours timepoint) and can be considered the worst-case effect. Based on the available eythema and edema scores and the longer exposure period (24 instead of 4 hours), it is concluded that interpretation of the study for CLP purposes is possible with the current test.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- The eye irritation information of this source substance is used for read across to Hyacinth body #3.
- Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- No examination was done 1 hour after instillation, observation for 7 days.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Housing: caged individually
- Other: the animals receive no hay or other extraneous material that might enter the eyes - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 mL testing material
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- SCORING SYSTEM: Draize and Kelley (1952)
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1, 2 and 4
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 5 and 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal: 2 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- Slight redness of the conjunctivae in four out of six rabbits and slight swelling (chemosis) of the conjunctivae in one out of six rabbits was noted. After seven days all lesions had cleared up.
- Interpretation of results:
- other: not eye irritating
- Remarks:
- Based on CLP criteria (EC 1272/2008 and its updates)
- Conclusions:
- Under the conditions of this test, Hyacinth body is not considered to be an eye irritant.
- Executive summary:
The eye irritation potential of Hyacinth body was tested in vivo using 6 New Zealand white rabbits. A Klimisch 2 rating was assigned as the test was performed similar to OECD 405 but with (acceptable) deviations on the observation period. Prior to instillation, eyes of the animals were examined for visible eye defects. 0.1 mL of testing material per animal was instilled in one eye and the other eye served as control. Eyes were not washed after instillation. Animals were observed at 24, 47, 72 and 7 days after instillation. No cornea and iris effects were noted. Slight redness of the conjunctivae in four out of six rabbits (with a mean (from 24, 48 and 72 hours) score 0.66 in 3 animals and a mean score 1 in one animal) and slight swelling (chemosis) of the conjunctivae in one out of six rabbits (mean score 0.33) were noted. After seven days all lesions had cleared up. Under the conditions of this test, Hyacinth body is not considered to be an eye irritant.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Information derived from analogue
- Justification for type of information:
- The read across justification is presented in the Irritation / corrosion Endpoint summary. The accompanying files are also attached there.
- Reason / purpose for cross-reference:
- read-across source
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1, 2 and 4
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 5 and 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Reversibility:
- fully reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal: 2 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Irritant / corrosive response data:
- Slight redness of the conjunctivae in four out of six rabbits and slight swelling of the conjunctivae in one out of six rabbits was noted. After seven days all lesions cleared up.
- Interpretation of results:
- other: not eye irritating
- Remarks:
- Based on CLP criteria (EC 1272/2008 and its updates)
- Conclusions:
- Eye irritation: not irritating (read-across from Hyacinth body tested in OECD TG 405).
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The skin and eye irritation is based on read across from Hyacinth body. First the information on Hyacinth body is presented and thereafter the read across justification is presented. The justification document is also attached in this endpoint summary.
Skin irritation
Information on Hyacinth body (CAS# 2556-10-7)
The skin irritation potential of Hyacinth body was tested in vivo using 12 New Zealand white rabbits (6 with intact skin and 6 with abraded skin). Study was performed similar to OECD 404 with some deviations on exposure time and observation period and therefore a Klimisch 2 rating was assigned. The test material was applied on the skin under a surgical patch. After an exposure period of 24 hours the patches were removed. Only testing results of 6 animals with intact skin are considered useful for evaluation of skin irritation. The animals were observed only at 48 hours after patch removal and no observations were done at time points of 24 and 72 hours. Effects observed directly upon patch removal were limited. Regarding erythema, 1 animal scored 3, 2 animals scored 2, 2 animals scored 1 and 1 animal scored 0, and regarding edema, 3 animals scored 1 and 3 animals scored 0. The dermal effects observed at 48 hours after patch removal were decreased to none to moderate erythema (1 animal scored 2, 2 animals scored 1 and 3 animals scored 0) and none to slight edema (1 animal scored 1 and 5 animals scored 0). Directly after patch removal only the erythema score for one animal was above the classification threshold (score 3). Although the study was not continued until the complete disappearance of the effects, the effects decreased largely within the 48 hours after patch removal. Given the longer exposure period of 24 instead of 4 hours and the test results obtained, it can be concluded that Hyacinth body is not an irritant to skin.
Eye irritation
Information on Hyacinth body (CAS# 2556-10-7)
The eye irritation potential of Hyacinth body was tested in vivo using 6 New Zealand white rabbits. A Klimisch 2 rating was assigned as the test was performed similar to OECD 405 but with (acceptable) deviations on the observation period. Prior to instillation, eyes of the animals were examined for visible eye defects. 0.1 mL of testing material per animal was instilled in one eye and the other eye served as control. Eyes were not washed after instillation. Animals were observed at 24, 47, 72 and 7 days after instillation. No cornea and iris effects were noted. Slight redness of the conjunctivae in four out of six rabbits (with a mean (from 24, 48 and 72 hours) score 0.66 in 3 animals and a mean score 1 in one animal) and slight swelling (chemosis) of the conjunctivae in one out of six rabbits (mean score 0.33) were noted. After seven days all lesions had cleared up. Under the conditions of this test, Hyacinth body is not considered to be an eye irritant.
Read-across justification
The skin and eye irritation properties of Hyacinth body #3 (CAS no. 7493-57-4, target) using read across from Hyacinth body (CAS no. 2556-10-7, source)
Introduction and hypothesis for the read across
Hyacinth body #3 has a benzyl ring with an ethyl chain to which an acetal is attached and another propyl chain. For this substance no relevant skin irritation data are available. Therefore additional information is used in accordance with Article 13 of REACH where it is said that lacking information should be generated whenever possible by means other than vertebrate animal tests, i.e. applying alternative methods such as in vitro tests, SARs, grouping and read-across.
Hypothesis: Hyacinth body #3 is expected to have the same skin and eye irritating properties as Hyacinth body.
Available information:
Skin irritation: The skin irritation potential of Hyacinth body was tested in vivo in rabbits in a study performed similar to OECD 404. Under the conditions of this test, some erythema and edema effects were observed directly after patch removal. Although the study was not continued until the complete disappearance of the effects, the effects decreased largely within the 48 hours after patch removal. Given the longer exposure period of 24 instead of 4 hours and the test results obtained, it can be concluded that Hyacinth body is not an irritant to skin.
Eye irritation: The eye irritation potential of Hyacinth body was tested in vivo in rabbits in a study performed similar to OECD 405. Slight effects in conjunctivae were noted, which cleared up after seven days. Under the conditions of this test, Hyacinth body is not considered to be an eye irritant.
Target and Source chemical(s)
Chemical structures of the target chemical (Hyacinth body #3) and the source chemical (Hyacinth body) are shown in the data matrix, including physico-chemical properties and toxicological information, thought relevant for skin and eye irritation.
Purity / Impurities
Hyacinth body #3 and Hyacinth body are mono-constituents. The impurities in both target and source are all below 2%.
Analogue justification
According to REACH Annex XI an analogue approach and structural alert information can be used to replace testing when information from different sources provides sufficient evidence to conclude that this substance has or does not have a particular dangerous property. The result derived should be applicable for C&L and/or risk assessment and be presented with adequate and reliable documentation.
Analogue selection: Hyacinth body was selected as read across analogue based on analogues found in QSAR Toolbox and RIFM and because it is a substance from IFF portfolio.
Structural similarities and differences: The target chemical Hyacinth body #3 and source chemical Hyacinth body have the same backbone (benzyl ring to which an ethyl and an alkyl chain is attached which is interrupted with the same functional acetal group). The structural difference is that the target Hyacinth body #3 has an additional methyl group compared to Hyacinth body.
Absorption: For skin and eye irritation absorption is a parameter which needs to be considered because most of irritant substances first have to be absorbed before cytotoxicity occurs. The target Hyacinth body #3 and the source Hyacinth body have the same absorption characteristics based on both substances being a liquid, based on molecular structure, weight and log Kow. The one methyl group less in Hyacinth body does not significantly change the absorption.
Reactivity: Reactivity is the key parameter for assessing the skin and eye irritation potential. The target chemical Hyacinth body #3 and source chemical Hyacinth body are expected to have the same reactivity, based on the fact that both have the same functional acetal group. The fact that the target substance Hyacinth body #3 has one additional methyl group compared to the source substance will not influence this.
Remaining uncertainties: There are no remaining uncertainties based on the reasoning above.
Conclusions on the skin irritation
When using read across, the result derived should be applicable for C&L and/or risk assessment and be presented with adequate and reliable documentation. For Hyacinth body #3 the skin and eye irritation information can be retrieved from Hyacinth body. The justification is presented in the present document. Hyacinth body #3 is not a skin or eye irritant because Hyacinth body is not a skin and eye irritant, as tested in similar to OECD TG 404 and 405, respectively.
Final conclusion on hazard and C&L: Hyacinth Body #3 is not a skin or eye irritant.
Data matrix for the read across from Hyacinth body to Hyacinth body #3
CHEMICAL NAME |
Hyacinth body #3 |
Hyacinth body
|
Molecular structure |
|
|
CAS |
7493-57-4 |
2556-10-7 |
Molecular formula |
C13H20O2 |
C12H18O2 |
REACH registration |
For 2018 |
For 2018 |
Einecs |
231-327-9 |
219-868-9 |
Tanimoto* |
1 |
0.93 |
Molecular weight |
208.30 |
194.28 |
Physico-chemical properties |
||
Appearance |
Liquid |
Liquid |
Melting point (˚C) |
32.27 (C) <-20 (M) |
21.75 (C) <-20 (M) |
Boiling point (˚C) |
272.67 (C) 263.4 (M) |
255.94 (C) 248.2 (M) |
Water solubility at 20˚C (mg/L) |
49.14 (C) 86.0 (M) |
152.3 (C) 453 (M) |
Log Kow |
3.40 (C) 4.1 (M) |
2.91 (C) 3.5 (M) |
Human health |
|
|
Skin irritation |
Read across from Hyacinth body |
Not skin irritating (OECD TG 404) |
Eye irritation |
Read across from Hyacinth body |
Not eye irritating (OECD TG 405) |
For testing data, see the IUCLID under the relevant endpoint. Calculated physico-chemical data were generated with EPISuite (version 4.1). C: calculated value, M: measured at IFF.
*Tanimoto calculation: http://chemmine.ucr.edu/similarity/#
Justification for classification or non-classification
Based on the results of the skin and eye irritation tests performed for the read-across analogue Hyacinth body, it can be concluded that Hyacinth body #3 does not need to be classified as an eye or skin irritant in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC) and its updates.
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