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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Version / remarks:
2001
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Test type:
acute toxic class method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-bromo-4-chloro-1-(propan-2-yl)benzene
EC Number:
696-543-1
Cas Number:
1369828-32-9
Molecular formula:
C9H10BrCl
IUPAC Name:
2-bromo-4-chloro-1-(propan-2-yl)benzene

Test animals

Species:
rat
Strain:
other: CRL:WI
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Remarks:
PEG 400
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
six females
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Conclusions:
A test material dose of 2000 mg/kg bw was tolerated by the female rats without mortalities, effects on body weight development and gross pathological findings. Clinical signs such as decreased activity (6/6), hunched back (6/6), prone position (2/6), piloerection (5/6), incoordination (3/6), could to touch (1/6) and decreased respiratory rate (1/6) were observed, but were reversible within a maximum of 3 days. Based on the results and according to EU classification criteria, the test substance is not to be classified.