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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The following remarks on the toxicokinetics of 2-benzofuran-1,3-dione, addition product with 2-(2-hydroxyethoxy)ethanol, ethoxylated are based on physicochemical properties of the compound and on toxicological data. Experimental toxicokinetic studies were not performed.
The substance is a colourless, clear organic liquid (Currenta, 2008) with a low vapour pressure under normal ambient conditions (8.9 Pa at 20 °C, 12.8 Pa at 25 °C, Currenta, 2009; 0.00513 Pa at 20 °C, Laus GmbH, 2010). Inhalation exposure via vapour is therefore not to be expected. Absorption of the substance via skin or mucosa could not be ruled out due to water solubility (4 g/L at 20 °C, CURRENTA, 2009) and a log Pow of 1.6, however due to the high average molecular weight of the substance it is expected to be low. In fact, no indications for systemic availability could be observed after acute oral or dermal exposure to the substance as there were no toxicological effects at all reported (OECD TG 423 and 402, both Gillissen, 2009). Also no indications of systemic availability appeared in a developmental toxicity study (OECD TG 414, Langewische, 2010) as no adverse effects were observed for the dams and for the offspring. Hints for systemic availability were seen in an oral repeated dose toxicity study where only for male rats of the high dose group (1000 mg/kg bw) slight effects on livers were observed (OECD TG 407, Potthoff, 2010).
There are no indications for irritating properties of the substance (OECD TG 404 and 405, both Gmelin, 2009) which might influence skin or mucosa barrier function and thus systemic availability.
Deducing from the repeated dose toxicity study where no other substance-related effects except liver findings were reported and from the above specified log Pow, no potential for accumulation is to be expected for the substance.
Based on the results of the genotoxicity tests in vivo and in vitro (OECD TG 471, Herbold, 2009; OECD TG 476, Entian, 2009; OECD TG 473, Nern, 2009) it could be concluded that DNA-reactive metabolites most probably will not be generated in mammalian organisms due to hepatic biotransformation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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