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Diss Factsheets
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EC number: 223-773-8 | CAS number: 4066-02-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1959-03-16 - 1959-09-07
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study conducted prior to GLP, no guideline followed as none was available in 1959, deficiencies in documentation, no analytical determination of the test concentration, mostly no standard species used.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 959
- Report date:
- 1959
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Animals were exposed over 4h to the vaporated test item
- GLP compliance:
- no
- Remarks:
- test conducted prior to GLP implementation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- IUPAC Name:
- 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- Test material form:
- other: vaporated solid
- Details on test material:
- - Name of test material (as cited in study report): 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan
- Substance type: pure substance
Constituent 1
Test animals
- Species:
- other: cat, rabbit, guinea pig, rat, mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice were exposed.
Administration / exposure
- Route of administration:
- inhalation: mist
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 400 L
- System of generating particulates/aerosols: heating of 20 g of the test item up to 150°C - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 2.25 mg/L
- No. of animals per sex per dose:
- 1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice
- Control animals:
- no
- Details on study design:
- - Other examinations performed: clinical signs
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 2.25 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: only dose tested, no animal regardless the species died during the study or showed signs of toxicity
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- >= 2.25 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: only dose tested, no animal regardless the species died during the study or showed signs of toxicity
- Mortality:
- none noted
- Clinical signs:
- other: no animal regardless the species showed any signs of toxicity
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Criteria used for interpretation of results: expert judgment
- Conclusions:
- Based on the available data, no absolute classification of the test item is possible. However, it can be stated that it does not need to be classified as acute toxic by inhalation category 1.
- Executive summary:
In an acute inhalation toxicity study, 1 cat, 1 rabbit, 1 guinea pig, 2 rats and 4 mice were exposed by inhalation route to 2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan for 4 hours to whole body at a concentration of 2.25 mg/L.
LC50> 2.25 mg/L
LC0≥ 2.25 mg/L
No animal regardless the species died during the study or showed signs of toxicity.
2,2'-Dioxy-3,3'-dicyclohexyl- 5-5'-dimethyl-diphenylmethan is classified as being of low toxicity.
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