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Diss Factsheets
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EC number: 927-186-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- [amino({4-[({5-[(3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbamoyl]-1-methyl-1H-1,3-benzodiazol-2-yl}methyl)amino]phenyl})methylidene]azanium 4-methylbenzene-1-sulfonate
- EC Number:
- 927-186-4
- Cas Number:
- 872728-85-3
- Molecular formula:
- C27 H29 N7 O3 x C7 H8 O3 S
- IUPAC Name:
- [amino({4-[({5-[(3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbamoyl]-1-methyl-1H-1,3-benzodiazol-2-yl}methyl)amino]phenyl})methylidene]azanium 4-methylbenzene-1-sulfonate
Constituent 1
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.46 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.46 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 62 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 8.8 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Five valid experiments were performed. In the first four experiments each, a EC50i-value could not derived fram the data, since the observed
immobility did not cover the respective effect range. As validity of the experiments was given, this was considered to be due to the test item
properties and the flat concentration-effect relationship observed for the test item. In the last experiment, the concentration range was expanded
and a clear concentrationeffect relationship could be observed. The evaluation of EC50i and NOEC was made using the data obtained in the last
experiment (main study). In addition, the EC50i value was determined based on the data obtained in all five valid experiments together.
The two 48h-EC50i-values showed to be comparable. The last experiment (main study) was performed using 10 concentrations ranging
fram 100 to 0.1 mg/L. In each treatment, twenty daphnia were exposed to the test item for 48 hours in a static test system. After 24 and 48 hours,
the immobilized daphnia were counted.
Seven treatments showed immobility between 0 and 100 %. These were used for the determination of the results.
The following results could be determined for the test item BIBR 1048 Amidin TS RS1 (species: Daphnia magna) based on the observations made
in the last experiment.
24h NOEC = 0.46 mg/L
24h EC50j = 62 mg/L
48h NOEC = 0.46 mg/L
48h EC50j = 8.8 mg/L
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