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Diss Factsheets
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EC number: 234-018-7 | CAS number: 10493-43-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Objective of study:
- absorption
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The objective of the study was to determine if the test substance undergoes absorption and metabolism after inhalation exposure in rats.
- GLP compliance:
- not specified
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Route of administration:
- inhalation
Doses / concentrationsopen allclose all
- Dose / conc.:
- 100 ppm
- Dose / conc.:
- 500 ppm
- Dose / conc.:
- 2 000 ppm
- Dose / conc.:
- 5 000 ppm
- Control animals:
- yes
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Tissue-to-air partition coefficients were collectively negative, and the data suggest that very little uptake of test substance occurs into tissues. According to the method used, it is likely that the blood-to-air partition of <0.5 would be observed. Thus only a small amount of the test substance would be inhaled, and after the end of exposure, the test substance that remains in the blood would be rapidly exhaled. This observation was supported by the preliminary gas uptake data.
Comparison of 2000 ppm exposure and control exposure indicated that the test substance does not undergo significant uptake and metabolism. At 100 ppm, an initial uptake of test substance is apparent in the first 75 minutes, but chamber concentration levels off indicating no further metabolism.
Applicant's summary and conclusion
- Conclusions:
- Only a small amount of the test substance would be inhaled, and after the end of exposure, the test substance that remains in the blood would be rapidly exhaled.
- Executive summary:
The objective of the study was to determine if the test substance undergoes absorption and metabolism after inhalation exposure in rats. Rats were exposed to concentrations of 0, 100, 500, 2000, or 5000 ppm via inhalation. Tissue-to-air partition coefficients were collectively negative, and the data suggest that very little uptake of test substance occurs into tissues. According to the method used, it is likely that the blood-to-air partition of <0.5 would be observed. Thus only a small amount of the test substance would be inhaled, and after the end of exposure, the test substance that remains in the blood would be rapidly exhaled. This observation was supported by the preliminary gas uptake data. Comparison of 2000 ppm exposure and control exposure indicated that the test substance does not undergo significant uptake and metabolism. At 100 ppm, an initial uptake of test substance is apparent in the first 75 minutes, but chamber concentration levels off indicating no further metabolism.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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