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Diss Factsheets
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EC number: 202-800-7 | CAS number: 99-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
For acute oral toxicity there is one animal study available conducted before implementation of the OECD guidelines. The study indicated a mouse LD50 oral 1207 (1150 -1267) mg/kg bw. This result needs to be considered for classification in category 4 (acute tox.4, H302).
There are no reliable reports whatsoever on acute dermal toxicity as well as acute inhalation toxicity in the public domain.
A mouse LD50 intraperitoneal 735 (691 -781) mg/kg bw was reported for 4-Chloroacetophenone from Bekemeier and Köster 1976.
A mouse LD50 intraperitoneal 100 mg/kg bw was reported from National Technical Information Service. However, the respective test substance is not specified as to its chemical form. Therefore this data entry is disregarded.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 207 mg/kg bw
Additional information
Please note that numerous studies are available describing the effects of chloroacetophenone, which however refer to the active ingredient CN in tear gas (CAS: 532 -27 -4, IUPAC name: 2 -chloro-1 -phenylethanone). In contrast to 2 -chloro-1 -phenylethanone, which is chlorinated at the side chain, 4´-chloroacetophenone (CAS: 99 -91 -02, IUPAC name: 1-(4-chlorophenyl)ethanone) is chlorinated at the core and therefore clearly less reactive. Thus studies using 2 -chloro-1 -phenylethanone are considered not representative for the toxicity assessment of 1-(4-chlorophenyl)ethanone.
Justification for classification or non-classification
1-(4-chlorophenyl)ethanone LD50 oral at 1207 (1150 -1267) mg/kg bw in mouse leads to classification in category 4 (acute tox.4, H302).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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