Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 206-137-4 | CAS number: 303-26-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Percent biodegradability of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no. 303-26-4) was estimated by using OECD QSAR tool box v3.3 using Log Kow as primary descriptor. Percent biodegradation of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine was determined to be 1 % by considering BOD as parameter and microorganisms as inoculum in 28 days. Based on % biodegrdability value it is concluded that this test chemical in not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1-[(4-chlorophenyl)(phenyl)methyl]piperazine(CAS No. 303 -26 -4). If released in to the environment, 6.01% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazinein sediment is estimated to be 541.66 days (3240 hrs). This Half life value in sediment indicates that test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine is persistent in sediment as well.
Biodegradation in Soil:
The half-life period of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine(CAS No. 303 -26 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazinein soil is estimated to be 120 days (2800 hrs). Based on this half-life value of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
Additional information
Biodegradation in water :
Predicted data studies for target chemical chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no. 303-26-4)and experimental studies for its read across chemicals have been studied and their results are summarized below for biodegradation water endpoint.
In first weight of evidence study the Percent biodegradability of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no. 303-26-4) was estimated by using OECD QSAR tool box v3.3 using Log Kow as primary descriptor. Percent biodegradation of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine was determined to be 1 % by considering BOD as parameter and microorganisms as inoculum in 28 days. Based on % biodegrdability value it is concluded that this test chemical in not readily biodegradable.
Second weight of evidence study was done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test compound 1-[(4-chlorophenyl)(phenyl)methyl]piperazine (CAS no. 303 -26 -4) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine is expected to be not readily biodegradable.
Next weight of evidence study was done from authoritative database (J Check, 2017) for structurally similar read across chemical in this study the biodegradation experiment was conducted for 14 days for evaluating the percentage biodegradability of read across substance Piperazine (CAS No: 110-85-0).Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l. The percentage degradation of read across substance obtained was 1.4% by BOD, 1% by TOC removal and 2.8% by GC parameter in 14 days. Thus, read across substance Piperazine (CAS No: 110-85-0) is considered to be not readily biodegradable in water.
Last weight of evidence study was also done from same source as mentioned above for red across chemical in this study the read across chemical 1-methyl-diethylenediamine (CAS no. 109-01-3) was subjected to biodegradation test by taking sludge as inoculums at 30 mg/L concentration. Biodegradation was analysed by using O2 Consumption, DOC removal and test material analysis by HPLC parameters. The initial concentration of read across chemical was 100 mg/L. After 4 weeks (28 days) test chemical showed 0% biodegradation by all three parameters mentioned above so it is concluded that this read across chemical 1-methyl-diethylenediamine is not readily biodegradable.
On the basis of results of above mentioned studies for target chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine( from OECD QSAR tool boxv3.3 and EPI suite) and supporting weight of evidence study ( from J Check, 2017). It is concluded that the test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine can be expected to be not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1-[(4-chlorophenyl)(phenyl)methyl]piperazine(CAS No. 303 -26 -4). If released in to the environment, 6.01% of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical in water is estimated to be 60 days (1440 hrs). The half-life (60 days estimated by EPI suite) indicates that the chemical is persistent in water and the exposure risk to aquatic animals is high whereas the half-life period of test chemical1-[(4-chlorophenyl)(phenyl)methyl]piperazinein sediment is estimated to be 541.66 days (3240 hrs). This Half life value in sediment indicates that test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine is persistent in sediment as well.
Biodegradation in Soil:
The half-life period of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine(CAS No. 303 -26 -4) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 74 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazinein soil is estimated to be 120 days (2800 hrs). Based on this half-life value of test chemical 1-[(4-chlorophenyl)(phenyl)methyl]piperazine, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.