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EC number: 207-529-8 | CAS number: 479-27-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: study based on OECDguideline 412 with a five days exposure
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 412 (Subacute Inhalation Toxicity: 28-Day Study)
- Deviations:
- yes
- Remarks:
- exposure 5 x 6 hours
- Principles of method if other than guideline:
- Ten male an ten female rats were exposed on 5 consecutive days for 6 hours per day nose/head only to an aerosol of 10, 75 or 394 mg 1,8-naphthylenediamine/m³ under dynamic conditions. The post-exposere time was 3 (intermediate section) or 17 days (endsection).
The animals were observed for mortality and clinical signs. In addition, clinical pathology of blood samples was performed. Organs and tissues were subjected to gross and histopathological investigation. - GLP compliance:
- yes
Test material
- Reference substance name:
- 1,8-naphthylenediamine
- EC Number:
- 207-529-8
- EC Name:
- 1,8-naphthylenediamine
- Cas Number:
- 479-27-6
- Molecular formula:
- C10H10N2
- IUPAC Name:
- naphthalene-1,8-diamine
- Details on test material:
- content: 99.5%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose/head only
- Vehicle:
- other: ethanol/polyethyleneglycol
- Duration of treatment / exposure:
- 6 hours each on 5 consecutive days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 10, 75 or 394 mg/m³
Basis:
analytical conc.
- No. of animals per sex per dose:
- 10 male and 10 female rats/dose
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- 75 mg/m³ air (analytical)
- Based on:
- test mat.
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
The exposition to the test substance was tolerated by all animals without mortality. Animals exposed to 394 mg/m³ 1,8-naphtylene- diamine revealed a decreased motility and a reduction in body weight gain.
A concentration dependant decrease of the rectal temperature was evident at a concentration of 10 mg/m³.
A decrease of the leucocyte number and an increase of the bilirubin concentration in plasma was found on animals exposed to 394 mg/m³.
The relative spleen weight was reduced in male rats at 394 mg testsubstance/m³.
All effects were reversible within the post-observation period.
Applicant's summary and conclusion
- Executive summary:
Ten male an ten female rats were exposed on 5 consecutive days for 6 hours per day nose/head only to an aerosol of 10, 75 or 394 mg 1,8-naphthylenediamine/m³ under dynamic conditions. The post-exposere time was 3 (intermediate section) or 17 days (endsection).
The animals were observed for mortality and clinical signs. In addition, clinical pathology of blood samples was performed. Organs and tissues were subjected to gross and histopathological investigation.
The exposition to the test substance was tolerated by all animals without mortality. Animals exposed to 394 mg/m³ 1,8-naphtylene- diamine revealed a decreased motility and a reduction in body weight gain. A concentration dependant decrease of the rectal temperature was evident at a concentration of 10 mg/m³. A decrease of the leucocyte number and an increase of the bilirubin concentration in plasma was found on animals exposed to 394 mg/m³. The relative spleen weight was reduced in male rats at 394 mg testsubstance/m³. All effects were reversible within the post-observation period.
Animals exposed to 394 mg 1,8-naphylenediamin revealed effects induced by the test material. Based on the hypothermic effect on animals exposed to 10 mg 1,8-naphthylendiamine a NOEL could not be established. The NOAEC is regarded to be 10 mg 1,8 -naphthylenediamine/m³.
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