Registration Dossier
Registration Dossier
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EC number: 225-083-2 | CAS number: 4651-67-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Toxicity to reproduction: other studies
Link to relevant study records
- Endpoint:
- toxicity to reproduction: other studies
- Remarks:
- QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Study period:
- 2017
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: QSAR prediction
- Conclusions:
- Prediction is Toxicant, the result appears reliable.
- Executive summary:
The prediction with “Developmental Toxicity model (CAESAR) 2.1.7" is “Toxicant”.
Overall, this property is judged as inconclusive for the classification.
- Endpoint:
- toxicity to reproduction: other studies
- Remarks:
- QSAR prediction
- Type of information:
- (Q)SAR
- Adequacy of study:
- other information
- Study period:
- 2017
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: QSAR prediction
- Conclusions:
- Prediction is Inactive, the result appears reliable.
- Executive summary:
The prediction with “Estrogen Receptor Relative Binding Affinity model (IRFMN)" is “Toxicant”.
Overall, this property is judged as inconclusive for the classification.
Referenceopen allclose all
Prediction is Toxicant, the result appears reliable.
Prediction is Inactive, the result appears reliable
Justification for classification or non-classification
Reproductive toxicity
Experimental data on the reproductive toxicity of 3-α-hydroxy-7-oxo-5-β-cholan-24-oic acid are not available.
The prediction with “Estrogen Receptor Relative Binding Affinity model (IRFMN)” is “Inactive”; by contrast prediction with "Developmental Toxicity model (CAESAR) 2.1.7" is “Toxicant”.
Effects on or via lactation
No information concerning this effect.
Overall, hazard class "Reproductive toxicity" are judged as inconclusive for the classification.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
