Registration Dossier
Registration Dossier
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EC number: 924-743-3 | CAS number: 253768-88-6
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
Ingestion: Never attempt to induce vomiting. Do not attempt to give any solid or liquidby mouth if the exposed subject is
unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty
of water to drink. Obtain medical attention.
Inhalation:Using appropriate personal protective equipment, move exposed subject to
fresh air. If breathing is difficult or ceases, ensure and maintain ventilation. Give oxygen
as appropriate. The exposed subject should be kept warm and at rest. Obtain medical
attention in cases of known or possible over exposure, or with symptoms including
chest pain, difficulty breathing, loss of consciousness or other adverse effects, which
may be delayed.
Skin contact: Using appropriate personal protective equipment, remove contaminated
clothing and flush exposed area with large amounts of water. Obtain medical attention
if skin reaction occurs, which may be immediate or delayed.
Eye contact: Wash immediately with clean and gently flowing water. Continue for at least
15 minutes. Obtain medical attention.
NOTES TO HEALTH PROFESSIONALS
Medical Treatment: Treat according to locally accepted protocols. For additional guidance, refer to the local poison
control informationcentre.
Health Surveillance Procedures: Pre-placement and periodic health surveillance is not usually indicated. The final determination
of the need for health surveillance should be determined by local risk assessment.
unconscious or semi-conscious. Wash out the mouth with water. If the exposed subject is fully conscious, give plenty
of water to drink. Obtain medical attention.
Inhalation:Using appropriate personal protective equipment, move exposed subject to
fresh air. If breathing is difficult or ceases, ensure and maintain ventilation. Give oxygen
as appropriate. The exposed subject should be kept warm and at rest. Obtain medical
attention in cases of known or possible over exposure, or with symptoms including
chest pain, difficulty breathing, loss of consciousness or other adverse effects, which
may be delayed.
Skin contact: Using appropriate personal protective equipment, remove contaminated
clothing and flush exposed area with large amounts of water. Obtain medical attention
if skin reaction occurs, which may be immediate or delayed.
Eye contact: Wash immediately with clean and gently flowing water. Continue for at least
15 minutes. Obtain medical attention.
NOTES TO HEALTH PROFESSIONALS
Medical Treatment: Treat according to locally accepted protocols. For additional guidance, refer to the local poison
control informationcentre.
Health Surveillance Procedures: Pre-placement and periodic health surveillance is not usually indicated. The final determination
of the need for health surveillance should be determined by local risk assessment.
Fire-fighting measures
Fire and Explosion Hazards: This material is non-combustible.Dust clouds are potentially very highly sensitive to ignition from incentive
electrostatic discharges. Dust clouds are of very low sensitivity to ignition from hot surfaces. No ignition or exotherm of a powder layer
observed up to 400 °C. Ignition of a dust cloud produces a strong dust explosion. Moderate pressure between 6 and 8 bar is produced
during a dust explosion.
Suitable Extinguishing Media:No special requirements needed. Water is recommended for fires involving packaging.
Special Protective Equipment and Precautions for Firefighters: Since toxic, corrosive or flammable vapours might be evolved from
fires involving this material,self contained breathing apparatus and full protective equipment are recommended for firefighters.
Move containers from the fire area if possible without increased personal risk.If possible, contain and collect firefighting water
for later disposal.
Specific Hazards arising from the Material: Toxic, corrosive or flammable thermal decomposition products, which might include
fluorine compounds, are expected when the material is exposed to fire.
electrostatic discharges. Dust clouds are of very low sensitivity to ignition from hot surfaces. No ignition or exotherm of a powder layer
observed up to 400 °C. Ignition of a dust cloud produces a strong dust explosion. Moderate pressure between 6 and 8 bar is produced
during a dust explosion.
Suitable Extinguishing Media:No special requirements needed. Water is recommended for fires involving packaging.
Special Protective Equipment and Precautions for Firefighters: Since toxic, corrosive or flammable vapours might be evolved from
fires involving this material,self contained breathing apparatus and full protective equipment are recommended for firefighters.
Move containers from the fire area if possible without increased personal risk.If possible, contain and collect firefighting water
for later disposal.
Specific Hazards arising from the Material: Toxic, corrosive or flammable thermal decomposition products, which might include
fluorine compounds, are expected when the material is exposed to fire.
Accidental release measures
Personal Precautions: Fence or cordon the affected area and do not allow individuals to
touch or walk through the spilled material unless wearing appropriate protective clothing. Avoid dust generation.
Environmental Precautions: Prevent entry into waterways, sewers, surface drainage
systems and poorly ventilated areas. If spill is outdoors, cover with plastic sheet to
minimize spreading or contact with rain.
Clean-up Methods: Collect and place it in a suitable, properly labelled container for
recovery or disposal. After all solid or absorbent material has been collected, the area
should be vacuumed with HEPA filter-equipped apparatus.
Decontamination Procedures: No specific decontamination or detoxification procedures have been identified for this material.Consider
use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of this SDS), for clean-up and decontamination
operations.
touch or walk through the spilled material unless wearing appropriate protective clothing. Avoid dust generation.
Environmental Precautions: Prevent entry into waterways, sewers, surface drainage
systems and poorly ventilated areas. If spill is outdoors, cover with plastic sheet to
minimize spreading or contact with rain.
Clean-up Methods: Collect and place it in a suitable, properly labelled container for
recovery or disposal. After all solid or absorbent material has been collected, the area
should be vacuumed with HEPA filter-equipped apparatus.
Decontamination Procedures: No specific decontamination or detoxification procedures have been identified for this material.Consider
use of water, detergent solutions, or other soluble solvents (if specified in Section 9 of this SDS), for clean-up and decontamination
operations.
Handling and storage
PRECAUTIONS FOR SAFE HANDLING
GSK Process Hazard Category: 4
General Requirements: Avoid dispersion as a dust cloud.
Depending upon the scale of operation, use of appropriate exhaust ventilation is recommended to
provide routine control of fire and explosion hazards during handling of this material.
Ignition Controls: Bond and earth (ground) all plant and equipment to ensure that no isolated conductors
are present. Isolated conductors can accumulate sufficient electrostatic charge to produce discharges
of many hundreds of milli-Joules.Consider earthing (grounding) personnel dealing with dusty operations.
An isolated (insulated) human body can readily produce electrostatic discharges in excess of 50 mJ, but
have been recorded up to 100 mJ.Minimise the use of plastics when handling this material. Handle and
store this material only in conductive or anti-static plastic liners (bags) since normal plastics are known to
be capable of producing electrostatic discharges of up to 4 mJ, ensuring that any containers into which
they are placed are themselves of a conductive material and earthed (grounded).The maximum surface
temperature of enclosures potentially exposed to this material should be the lower of the values
obtained by taking 2/3 of the minimum ignition temperature for a dust cloud or 75 K less than the
minimum ignition temperature of the dust layer, with a maximum temperature of 325 °C.
Protective Systems: Assess operations based upon available dust explosion information to determine the
suitability of preventive or protective systems as precautionary measures against possible dust
explosions. If prevention is not possible, consider protection by use of containment, venting or
suppression of dust handling equipment. Where explosion venting is considered the most appropriate
method of protection, vent areas should preferably be calculated based on the Kst rather than the St
value. If nitrogen purging is considered as the protective system, it must operate with an oxygen level
below the limiting oxygen concentration. The system should include an oxygen monitoring and shut-
down facility in the event of excessive oxygen being detected. At both ambient and low humidity, this
material is of appreciable conductivity. Generation and accumulation of electrostatic charge is
considered unlikely to occur when handled in an earthed (grounded) environment. At both ambient and
low humidity, this material has a fast charge relaxation time. Accumulation of electrostatic charge is
considered unlikely to occur when handled in an earthed (grounded) environment. At the end of the
charge accumulation process charges is expected to be readily lost to earth (ground).
CONDITIONS FOR SAFE STORAGE
Keep in tightly closed containers or packages away from moisture and away from sources of ignition.Avoid prolonged storage at elevated temperatures (greater than room temperature, approximately 20 degrees C).
Transport information
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Marine transport (UN RTDG/IMDG)
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Exposure controls / personal protection
OCCUPATIONAL EXPOSURE LIMIT
GSK Occupational Hazard Category:1
GSK Occupational Exposure Limit: 5000 MCG/M3 (8 HR TWA)
ENGINEERING CONTROLS
Exposure Controls: An Exposure Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are assigned and how to interpret them.
Containment: No special engineering controls are required.
Ventilation: Local exhaust ventilation (LEV) is recommended.
Administrative: Only authorized personnel may enter the working area.
PERSONAL PROTECTIVE EQUIPMENT
Eye Protection: Wear approved safety glasses with side shields or cover goggles if eye contact is possible.
Gloves: The selection of gloves for a specific activity must be based on the material's properties and on
possible permeation and degradation that may occur under the circumstances of use. Glove selection
must take into account any solvents and other hazards present. Potential allergic reactions can occur
with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised
if insufficient data are available and further guidance should be sought from your local EHS department
Respirators: If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air
concentrations present, required protection factor as well as hazards, physical properties and
warning properties of substances present. Follow local regulations for respirator use in the
workplace.
Other Equipment or Procedures: An eye wash station should be available.
GSK Occupational Hazard Category:1
GSK Occupational Exposure Limit: 5000 MCG/M3 (8 HR TWA)
ENGINEERING CONTROLS
Exposure Controls: An Exposure Control Approach (ECA) is established for operations involving this material based upon the OEL/Occupational Hazard Category and the outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for more information about how ECA's are assigned and how to interpret them.
Containment: No special engineering controls are required.
Ventilation: Local exhaust ventilation (LEV) is recommended.
Administrative: Only authorized personnel may enter the working area.
PERSONAL PROTECTIVE EQUIPMENT
Eye Protection: Wear approved safety glasses with side shields or cover goggles if eye contact is possible.
Gloves: The selection of gloves for a specific activity must be based on the material's properties and on
possible permeation and degradation that may occur under the circumstances of use. Glove selection
must take into account any solvents and other hazards present. Potential allergic reactions can occur
with certain glove materials (e.g. Latex) and therefore these should be avoided. Care must be exercised
if insufficient data are available and further guidance should be sought from your local EHS department
Respirators: If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air
concentrations present, required protection factor as well as hazards, physical properties and
warning properties of substances present. Follow local regulations for respirator use in the
workplace.
Other Equipment or Procedures: An eye wash station should be available.
Stability and reactivity
Conditions to Avoid: Avoid direct sunlight, conditions that might generate heat and dispersion as a dust cloud.
Disposal considerations
Disposal Recommendations: Collect for recycling or recovery if possible. The recommended method of disposal is
incineration.Wherever possible, disposal should be in an on-site licensed chemical incinerator, if allowed by the
incinerator license or permit. If no on-site incinerator is available, dispose of material in a licensed commercial
chemical incinerator.
Regulatory Requirements: Observe all local and national regulations when disposing of this material.
incineration.Wherever possible, disposal should be in an on-site licensed chemical incinerator, if allowed by the
incinerator license or permit. If no on-site incinerator is available, dispose of material in a licensed commercial
chemical incinerator.
Regulatory Requirements: Observe all local and national regulations when disposing of this material.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
