3,4-dihydroxy-5-nitrobenzaldehyde

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

other: Body responsible for the test

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method B.3 (Acute Toxicity (Dermal))

GLP compliance:

yes

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

441-810-8

EC Name:

-

Cas Number:

116313-85-0

Molecular formula:

C7H5NO5

IUPAC Name:

3,4-dihydroxy-5-nitrobenzaldehyde

Test animals

Species:

rat

Strain:

Sprague-Dawley

Administration / exposure

Type of coverage:

semiocclusive

Duration of exposure:

24 h

Results and discussion

Mortality:

Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0

Clinical signs:

other: Signs of toxicity related to dose levels: During the test period no signs of systemic toxicity were observed. The bodyweight development was as expected.

Gross pathology:

Effects on organs: No abnomalities were found.

Other findings:

Signs of toxicity (local): Yellowish discolouring of the test area was found in all animals 1 to 4 days p.a. which prevented an assessement of
erythema. During this period no signs of oedema were found.
Desquamation were observed at the treatment areas of 4 males and 4 females 3 to 6 days p.a.. Yellowish discolouring were observed from day 5 but this did not have any effect in the assessment of the erythema.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU