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EC number: 219-411-3 | CAS number: 2432-87-3
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
The Biodegradation experiment was carried out of test chemical 1,10-dioctyl decanedioate (CAS no. 2432-87-3) by taking activated sludge as inoculums at 30 mg/L concentration for 21 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC .The initial concentration of test chemical was 100 mg/L. The study design was of standard type. After 3 weeks of incubation percent biodegradation of test chemical1,10-dioctyl decanedioate was observed to be 78.2 % by BOD parameter 100 % by test material analysis by GC parameter in 21 days.Therefore it is concluded that test chemical1,10-dioctyl decanedioate is readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1,10-dioctyl decanedioate (CAS No.2432 -87 -3). If released in to the environment, 23 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical 1,10-dioctyl decanedioate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical 1,10-dioctyl decanedioate in sediment is estimated to be 135 days (3240 hrs). However as the percent release of test chemical 1,10-dioctyl decanedioate into sediment is less than 1 % (i.e., reported as 0.374% ) indicates that test chemical 1,10-dioctyl decanedioate is not persistant in sediments.
Biodegradation in Soil:
The half-life period of test chemical 1,10-dioctyl decanedioate (CAS No. 2432-87-3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 76 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 1,10-dioctyl decanedioate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical 1,10-dioctyl decanedioate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
Additional information
Biodegradation in water:
Experimental data and predicted data for the target compound1,10-dioctyl decanedioate (CAS no. 2432-87-3) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:
In a first weight of evidence study the Biodegradation experiment was carried out of test chemical 1,10-dioctyl decanedioate (CAS no. 2432-87-3) by taking activated sludge as inoculums at 30 mg/L concentration for 21 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC . The initial concentration of test chemical was 100 mg/L. The study design was of standard type. After 3 weeks of incubation percent biodegradation of test chemical 1,10-dioctyl decanedioate was observed to be 78.2 % by BOD parameter 100 % by test material analysis by GC parameter in 21 days. Therefore it is concluded that test chemical 1,10-dioctyl decanedioate is readily biodegradable.
Next weight of evidence study was prediction in this the biodegradability of test chemical 1,10-dioctyl decanedioate (CAS no. 2432 -87 -3) was predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical 1,10-dioctyl decanedioate showed 81.80 % biodegradation by considering BOD as parameter and microorganism as inoculum in 28 days. Therefore it is concluded that test chemical 1,10-dioctyl decanedioate is readily biodegradable.
Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test compound1,10-dioctyl decanedioate (CAS no. 2432-87-3) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 1,10-dioctyl decanedioate is expected to be readily biodegradable.
In a supporting weight of evidence study from authoritative database (J Check, 2017) the Biodegradation experiment was carried out of read across chemical 1,6-bis(2-ethylhexyl) hexanedioate (CAS no. 103-23-1)by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by GC. The initial concentration of read across chemical was 100 mg/L. The study design was of standard type. After 4 weeks of incubation percent biodegradation of read across chemical1,6-bis(2-ethylhexyl) hexanedioate was observed to be 71 % by BOD parameter 85 % by test material analysis by GC parameter .Therefore it is concluded that read across chemical 1,6-bis(2-ethylhexyl) hexanedioate is readily biodegradable.
In another supporting weight of evidence study from authoritative database (J Check, 2017) Biodegradability of read across chemical didodecyl 3,3'-sulfanediyldipropanoate (CAS no. 123-28-4) was determined by taking activated sludge as inoculums at 30 mg/L concentration for 28 days. Biodegradation was analyzed by using two parameters that are BOD and test material analysis by HPLC. The initial concentration of read across chemical was 100 mg/L and study design was of standard type. After 4 weeks of incubation Percent biodegradation of read across chemical didodecyl 3,3'-sulfanediyldipropanoate was observed to be 82 % by BOD parameter and 97% by test material analysis by HPLC parameter in 28 days. Therefore it is concluded that read across chemical didodecyl 3,3'-sulfanediyldipropanoate is readily biodegradable.
On the basis of results of above mentioned studies for target chemical 1,10-dioctyl decanedioate (CAS no. 2432-87-3) (From J Check, OECD QSAR tool boxv3.3 and EPI suite) and supporting weight of evidence study ( from J Check, 2017). It is concluded that the test chemical 1,10-dioctyl decanedioate (CAS no. 2432-87-3) can be expected to be readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 1,10-dioctyl decanedioate (CAS No.2432-87-3). If released in to the environment, 23 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of test chemical 1,10-dioctyl decanedioate in water is estimated to be 15 days (360 hrs). The half-life (15 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is moderate to low whereas the half-life period of test chemical 1,10-dioctyl decanedioate in sediment is estimated to be 135 days (3240 hrs). However as the percent release of test chemical 1,10-dioctyl decanedioate into sediment is less than 1 % (i.e., reported as 0.374% ) indicates that test chemical 1,10-dioctyl decanedioate is not persistant in sediments.
Biodegradation in Soil:
The half-life period of test chemical 1,10-dioctyl decanedioate (CAS No. 2432-87-3) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 76 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 1,10-dioctyl decanedioate in soil is estimated to be 30 days (720 hrs). Based on this half-life value of test chemical 1,10-dioctyl decanedioate, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is low.
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