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EC number: 605-937-4 | CAS number: 18162-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2007-06-28 to 2007-11-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline under GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 92/69/EWG, C.2; OECD 202 (2004)
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(Morpholinomethyl)triethoxysilane
- IUPAC Name:
- N-(Morpholinomethyl)triethoxysilane
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- All concentrations at 0 and 48 h
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: No vehicle used.
The highest test concentration of nominal 144 mg/l was prepared by dissolving 316.7 mg of test item into 2200 ml of culture medium and by intense stirring for 24 h.
Since the test item undergoes rapid hydrolysis and as there was no specific analytical method available, analyses was performed by determination of the DOC (Dissolved organic carbon) content as sum parameter in the test media.
At the start of the test just before introduction of the Daphnia 97% of the nominal test concentration were found. After 48 hours test duration 90 % of the nominal values were determined. Thus during the test period of 48 hours the Daphnia were exposed to a mean of 93% of nominal.
Only at 0h in the test concentrations 100-144 mg/L slight prcipitation was observed after preaparation of the test item
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Straus, clone 5
- Source: ECT Oekotoxikologie GmbH, Flörsheim, Germany
- Age at study initiation (mean and range, SD): 2.5 to 18 hours
- Feeding during test: no
ACCLIMATION
not necessary
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- no
Test conditions
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 19-21 °C
- pH:
- 7.7-8.4
- Dissolved oxygen:
- 7.9-9.1 mg/L
- Salinity:
- 0.9 mmol/L
- Nominal and measured concentrations:
- 0, 69, 83, 100, 120, 144 mg/L nominal
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass beakers of 100 mL containing 80 mL of culture medium
- Type (delete if not applicable): closed with a lid to reduce loss of water
- Renewal rate of test solution (frequency/flow rate):-
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
see above
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16 h
- Light intensity: 350 - 570 lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
The immobility of the Daphnia was determined by visual controls after 24 and 48 h. Those animals not able to swim within 15 seconds after gentle agitation of the test beaker were considered to be immobile.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: < 2.2
- Range finding study
- Test concentrations: <100 mg/L nominal
- Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate (twice a year)
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 120 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 144 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 144 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mobility
- Details on results:
- - Behavioural abnormalities: no
- Other biological observations: no
- Mortality of control: 0
- Other adverse effects control: no
- Abnormal responses: no
- Effect concentrations exceeding solubility of substance in test medium: no
At the test concentration of 144 mg/L one daphnia was immobile, which was not assessed as significant by statistical evaluation - Results with reference substance (positive control):
- no details
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- N-(Morpholinomethyl)triethoxysilane VP was not toxic to the water flea Daphnia magna under the conditions of the test.
- Executive summary:
To assess the acute toxicity of N-(Morpholinomethyl)triethoxysilane to aquatic invertebrates (Daphnia magna) a test according to OECD 202 (EU Guideline 92/92/EEC C.2) was performed. In the control and the concentrations 69, 83, 100 and 120 mg/L (nominal) no immobile daphnias were observed. At the test concentration of 144 mg/L one daphnia was immobile, which was not assessed as significant by statistical evaluation. The measured concentrations were at least 93% of the nominal. Based on this N-(Morpholinomethyl)triethoxysilane is not considerd to be toxic to Daphnia magna.
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