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EC number: 221-043-3 | CAS number: 2983-37-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- study performed before implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl 2-ethylhexanoate
- EC Number:
- 221-043-3
- EC Name:
- Ethyl 2-ethylhexanoate
- Cas Number:
- 2983-37-1
- Molecular formula:
- C10H20O2
- IUPAC Name:
- ethyl 2-ethylhexanoate
- Details on test material:
- - Name of test material (as cited in study report): 2-ethyl-ethyl-capronat
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Weight at study initiation: approx. 24 g
- Fasting period before study: yes
- Housing: no data
- Diet (e.g. ad libitum): Altromin maintainance diet, Nr. 1324
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): approx. 50%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 79 - 315 g/L
- Purity: 2% CMC/MED/Type 70
MAXIMUM DOSE VOLUME APPLIED: 20 cm³/kg bw for all dose levels - Doses:
- 1680, 1990, 3160, 3980, 5010, 5600, 6310 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: day 0 (prior to administration); after 48 h, 1 week, 2 weeks
- Necropsy of survivors performed: only 3-6 animals per dose group were examined after necropsy - Statistics:
- Litchfield and Wilcoxon (J. Pharm. exptl. ther. 96, 99 - 108 (1949))
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 450 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- >= 3 800 - <= 5 210
- Mortality:
- 1680 mg/kg bw: 0/10 animals died;
1990 mg/kg bw: 1/10 animals died;
3160 mg/kg bw: 3/10 animals died;
3980 mg/kg bw:4/10 animals died;
5010 mg/kg bw: 5/10 animals died;
5600 mg/kg bw: 7/10 animals died;
6310 mg/kg bw: 10/10 animals died - Clinical signs:
- reduced breathing frequency, reduced activity, abnormal posture
- Body weight:
- body weight gain of surviving animals was similar in all dose groups
- Gross pathology:
- no findings in examined animals
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified according to CLP regulation
- Conclusions:
- Based on the results obtained after a single oral administration to male mice, the oral LD50 of 2-Ethyl ethyl capronate was determined to be 4450 mg/kg bw.
- Executive summary:
In an acute oral toxicity study similar to OECD guideline 401, groups of 10 fasted male CF-1 mice were given a single oral dose of 2-Ethyl ethyl capronate at doses of 1680, 1990, 3160, 3980, 5010, 5600 and 6310 mg/kg bw and observed for 14 days.
The following mortality was observed: 0/10 at 1680 mg/kg bw; 1/10 at 1990 mg/kg bw; 3/10 at 3160 mg/kg bw; 4/10 at 3980 mg/kg bw; 5/10 at 5010 mg/kg bw; 7/10 at 5600 mg/kg bw; 10/10 at 6310 mg/kg bw.
The surviving animals showed reduced activity after 2 and 24 h, reduced breathing frequency after 2 h and abnormal posture after 2 h.
No changes in body weight gain were observed in the surviving animals throughout all dose groups.
The oral LD50 was determined to be 4450 mg/kg bw (95% c.i. 3800 – 5210 mg/kg bw).
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