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EC number: 230-386-8 | CAS number: 7085-19-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 November 1982 to 11 January 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Mecoprop
- EC Number:
- 230-386-8
- EC Name:
- Mecoprop
- Cas Number:
- 7085-19-0
- Molecular formula:
- C10H11ClO3
- IUPAC Name:
- 2-(4-chloro-2-methylphenoxy)propanoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: Animals were given no feed 16 hours before administration, but water was available ad libitum.
- Housing: Animals were housed in stainless steel wire mesh cages. 5 animals per cage.
- Water: Tap water available ad libitum
- Acclimation period: At least one week
ENVIRONMENTAL CONDITIONS
- Temperature: 20 - 24 °C
- Humidity: 30 - 70 %
- Photoperiod: 12 Hours dark/12 Hours light (06.00 - 18.00 hours/ 18.00 - 06.00 hours)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- (0.5 % aqueous)
- Details on oral exposure:
- TEST MATERIAL:
- Vehicle: 0.5 % aqueous carboxymethyl cellulose forming a suspension with the test material.
- Amount applied: 10 mL/kg
- Concentration: 6.81 % w/v (681 mg/kg), 10.00 % w/v (1000mg/kg), 14.70 % w/v (14.70 mg/kg), 21.50 % w/v (2150 mg/kg) - Doses:
- 681, 1000, 1470, 2150 mg/kg
- No. of animals per sex per dose:
- 5 males and 5 females per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Recording of signs and symptoms several times on the day of administration, at least once each workday. Checks for moribund and dead animals twice each workday and once on holidays.
- Necropsy of survivors performed: yes, withdrawal of food 16 hours before sacrifice with CO2; then necropsy with gross-pathological examination performed.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 166 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 004 - <= 1 362
- Mortality:
- Mortality was observed at dose levels 1000, 1470 and 2150 mg/kg in both female and male animals. At dose 1000 mg/kg, 2/10 animals had died by day 14, at dose 1470 mg/kg 9/10 animals had died by day 14 and at dose 2150 mg/kg 9/10 animals had died by day 14.
- Clinical signs:
- other: No abnormalities were observed at dose level 681 mg/kg during the observation period. At the higher dose levels, a wide range of symptoms were observed for both female and male animals, these include: Dyspnea, apathy, abnormal positioning, staggering, ato
- Gross pathology:
- Animals that died:
- General congestion.
- Stomach: bloody ulcerations in the glandular stomach in some animals; injected vessels.
- Intestines: Slightly atonic and contents mixed with blood in some animals.
- Urinary bladder: Strikingly filled in some animals.
Sacrificed animals:
- One animal (2150 mg/kg): Tip of the forestomach thickened; adhesions of the forestomach to the peritoneum and liver.
Remaining animals:
- Organs: no abnormalities detected.
Any other information on results incl. tables
Mortality During the Study
Dose (mg/kg) | 2150 | 1470 | 1000 | 681 | |
Males | |||||
Number of Animals | 5 | 5 | 5 | 5 | |
Number of Dead Animals After: | 1 h | 0 | 0 | 0 | 0 |
1 d | 0 | 0 | 0 | 0 | |
2 d | 4 | 3 | 1 | 0 | |
7 d | 4 | 5 | 1 | 0 | |
14 d | 4 | 5 | 1 | 0 | |
Females | |||||
Number of Animals | 5 | 5 | 5 | 5 | |
Number of Dead Animals After: | 1 h | 0 | 0 | 0 | 0 |
1 d | 2 | 2 | 0 | 0 | |
2 d | 5 | 4 | 1 | 0 | |
7 d | 5 | 4 | 1 | 0 | |
14 d | 5 | 4 | 1 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: EU Category 4, H302 Harmful if swallowed
- Conclusions:
- Under the conditions of this study, the acute oral LD50 of the test material was 1166 mg/kg for males and females.
- Executive summary:
The acute oral toxicity of the test material was investigated in a study similar in design to OECD 401.
Five male and five female Wistar rats were treated orally with the test material at doses of: 681, 1000, 1470 and 2150 mg/kg in a single administration by gavage. The animals were observed for 14 days, before gross necropsy was performed.
Mortality and clinical abnormalities were observed at dose levels 1000, 1470 and 2150 mg/kg, body weights increased during the observation period at all doses. In the animals that died, the gross pathology found abnormalities such as stomach ulcers, slightly atonic intestines and strikingly filled bladders in some animals. In the sacrificed animal, tip of the forestomach thickened. In the remaining animals, no abnormalities were observed.
Under the conditions of this study, the acute oral LD50 of the test material was 1166 mg/kg.
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