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EC number: 257-471-2 | CAS number: 51850-20-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In a guideline GLP study, the acute oral LD50 value of hexahydroxoplatinum(IV) acid was determined to exceed 2150 mg/kg bw (limit test) in rats (Berthold, 1995a).
No relevant acute dermal or inhalation toxicity data were identified.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 March-12 April 1995
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD Guideline, to GLP, with a minor deviation (humidity) that would not be expected to affect results
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Relative humidity was below the protocol-stated range twice (for around 1 hour)
- Qualifier:
- according to guideline
- Guideline:
- other: EEC Guideline 92/32/EEC
- Deviations:
- yes
- Remarks:
- Relative humidity was below the protocol-stated range twice (for around 1 hour)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: HsdCpb: WU
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan-Winkelmann GmbH, D-33176 Borchen
- Age at study initiation: 9 weeks (males); 10 weeks (females)
- Weight at study initiation: 218-225 g (males); 159-170 g (females)
- Fasting period before study: Approximately 16 hours
- Housing: Macrolon cages, type II
- Diet (e.g. ad libitum): ssniff R special diet for rats (ad libitum)
- Water (e.g. ad libitum): From Stadtwerke Halle (utility service provider), using an automatic drinking water system with drinking nipples or drinking bottles (ad libitum)
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-22
- Humidity (%): 34-61
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): 12/12 - Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- Aqueous CMC 0.5% (Registered trademark name Tylose; Tylopur C 1000 P)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 215 mg/ml
- Amount of vehicle (if gavage): 10 ml/kg
- Justification for choice of vehicle: None given
- Lot/batch no. (if required): E 11430100
- Purity: No data
DOSAGE PREPARATION: Suspension, prepared using a homogenizer - Doses:
- 2150 mg/kg bw (males and females)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed continuously for 4-6 hours after administration; then once/day
- Necropsy of survivors performed: yes
- Other examinations performed: mortality and clinical signs (at least once/day), body weight (days 0, 7, 14) - Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 150 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CL not applicable
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 150 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: CL not applicable
- Mortality:
- None
- Clinical signs:
- other: Stilted gait (seen between 55 minutes and 1 day after administration) in 1 male and 3 females. Sunken sides (seen between 55 minutes and 1 day after administration) in 1 male and 4 females.
- Gross pathology:
- No significant findings
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In a guideline GLP study, the acute oral LD50 value of hexahydroxoplatinum(IV) acid was determined to exceed 2150 mg/kg bw (limit test) in rats.
- Executive summary:
In a well-conducted acute oral toxicity test, conducted in accordance with OECD Test Guideline 401 and to GLP, HsdCpb: WU rats (5/sex) were gavaged with hexahydroxoplatinum(IV) acid (as a suspension in aqueous carboxymethyl cellulose) at a limit dose of 2150 mg/kg bw and observed for 14 days.
Transient clinical signs of stilted gait and sunken sides were apparent in some animals. No deaths were observed within the observation period. The oral LD50 (and indeed the LD0) was therefore determined to exceed 2150 mg/kg bw in male and female rats.
Based on the results of this study, no classification for acute oral toxicity is required according to EU CLP criteria (EC 1272/2008).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- Overall, good-quality database which meets REACH Standard Information Requirements.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No relevant human acute toxicity data were identified.
In a well-conducted acute oral toxicity test, conducted in accordance with OECD Test Guideline 401 and to GLP, HsdCpb: WU rats (5/sex) were gavaged with hexahydroxoplatinum(IV) acid (as a suspension in aqueous carboxymethyl cellulose) at a limit dose of 2150 mg/kg bw and observed for 14 days. Transient clinical signs of stilted gait and sunken sides were apparent in some animals. No deaths were observed within the observation period. The oral LD50 (and indeed the LD0) was therefore determined to exceed 2150 mg/kg bw in male and female rats (Berthold, 1995a)
No acute inhalation toxicity data were identified. However, the compound is not expected to reach the lungs in appreciable quantities (based on respiratory tract deposition modelling data). Thus, inhalation will not be a significant route of exposure.
Similarly, no acute dermal toxicity data were identified. However, skin contact during production and/or use is expected to be negligible.
Justification for classification or non-classification
Based on the results of the available and reliable acute oral toxicity study in rats, dihydrogen hexahydroxyplatinate does not require classification for acute oral toxicity according to EU CLP criteria (EC 1272/2008).
No evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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