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Diss Factsheets
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EC number: 300-340-2 | CAS number: 93925-38-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 28 December 1987 to 11 january 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR Part 1500
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Charles River Breeding laboratories, Inc, Wilmington, MA- Age at study initiation: Young adult-Weight at study initiation: 224 to 316g- Fasting period before study: Overnight before day of dosing- Housing: Individually in wire mesh bottom cages- Diet (e.g. ad libitum): NIH Open Formula 07 (Zeigler Brothers) ad libitum- Water (e.g. ad libitum): tap water ad libitum- Acclimation period: Minimum of 5 daysENVIRONMENTAL CONDITIONSConformed to standards established in "Guide for the care and use of Laboratory animals" DHEW Publication No (NIH) 85-23.IN-LIFE DATES: From: 28 December 1987 To: 11 January 1988
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE- Concentration in vehicle: None, dosed as suppliedMAXIMUM DOSE VOLUME APPLIED: Not reported
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 Days- Frequency of observations and weighing: Three times on day of dosing, daily thereafter.- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight,
- Statistics:
- Not applicable
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No premature deaths were recorded. All animals survived to study termination (Day 15).
- Clinical signs:
- other: Decreased acitivity, diarrhea and apparent urinary incontinence were noted following dose administration. Three female rats exhibited hair loss on the hind legs. This finding started on days 5, 9 and 12, respectively, and continued to the end of the study
- Gross pathology:
- No gross lesions were noted in the five male and five female rats examined grossly at study termination.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material gave an LD50 value greater than 5000 mg/kg in the rat.
- Executive summary:
Test Guidance
US EPA 16 CFR Part 1600.
Method
The test substance was administered by gavage to each of five male and five female Sprague-Dawley rats at a dose level of 5000 mg/kg body weight. The animals were observed for pharmacotoxic signs and mortality for 15 days.
Results
All animals survived the 15 day post-adminstration period.
Conclusion
The test material gave an LD50 value greater than 5000 mg/kg in the rat.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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