2-bromoethylammonium bromide

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from Authoritive Database

Data source

Reference

Reference Type:

other: Authoritive Database

Title:

Skin irritation for CAS NO: 60-00-4

Author:

IFA (GESTIS)

Year:

2017

Bibliographic source:

GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn)

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

A Skin irritation study was conducted in rabbits to assess the irritation potential of Ethylenediaminetetraacetic acid (EDTA)

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid

Cas Number:

60-00-4

Molecular formula:

C10H16N2O8

IUPAC Name:

2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid

Test material form:

solid

Details on test material:

2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid /60-00-4/200-449-4
- Name of test material (as cited in study report): Ethylenediaminetetraacetic acid (EDTA)
- Molecular formula: C10H16N2O8
- Molecular weight: 292.3 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles: N(CCN(CC(O)=O)CC(O)=O)(CC(O)=O)CC(O)=O
-InChI: 1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1 6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)

Specific details on test material used for the study:

2,2',2'',2'''-(ethane-1,2-diyldinitrilo)tetraacetic acid /60-00-4/200-449-4
- Name of test material (as cited in study report): Ethylenediaminetetraacetic acid (EDTA)
- Molecular formula: C10H16N2O8
- Molecular weight: 292.3 g/mol
- Substance type: Organic
- Physical state: Solid
-Smiles: N(CCN(CC(O)=O)CC(O)=O)(CC(O)=O)CC(O)=O
-InChI: 1S/C10H16N2O8/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20/h1 6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20)

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

No Data Available

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

50% aqueous solution

Duration of treatment / exposure:

No Data Available

Observation period:

20 hours

Number of animals:

No Data Available

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 20 hours

Score:

0

Reversibility:

not specified

Remarks on result:

no indication of irritation

Irritant / corrosive response data:

No skin irritating effects were observed.

Applicant's summary and conclusion

Interpretation of results:

other: not irritating

Conclusions:

No known signs of irritation were observed after 20 days. Hence, Ethylenediaminetetraacetic acid (CAS No: -60-00-4) wasconsidered to be non irritating to the rabbits skin.

Executive summary:

Skin irritation study was carried out on rabbits to assess the irritation potential of test chemical Ethylenediaminetetraacetic acid (CAS No: -60-00-4).

The skins of rabbits were exposed to the test chemical at concentration of 50% in aqueous solution and skin reactions were observed up to 20 days.

No known signs of irritation were observed after 20 days. Hence, Ethylenediaminetetraacetic acid (CAS No: -60-00-4) wasconsidered to be non irritating to the rabbits skin.