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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Reliability score 2 on the basis of the weight of evidence found during review of public documents existing relating to toxicological data
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Four New Zealand White rabbits of each sex were exposed for 24 h with a bandage containing doses of 2.0 or 3.0 g/kg body weight of white spirit (Stoddard solvent) (14.5% aromatics). The exposed area, which measured about 10% of the body surface, was shaved before exposure and the skin of two animals in each dose group was abraded.
The rabbits were observed for a period of 14 days. - GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- C9-C12 Mixed aliphatics and aromatics (8052-41-3) Boiling Point Range 160-199 °C
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 5 male/female rabbits
TEST ANIMALS- Source: Alpine Laboratory Rabbits- Age at study initiation: Young adult
- Weight at study initiation: 1.9-2.40 kg at time of dosing
- Housing: Individually
- Diet (e.g. ad libitum): Purina rabbit chow, ad libitum
- Water (e.g. ad libitum): ad libitum- Acclimation period: 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 68 - 74 °F
- Humidity (%): 31 - 70% relative humidity
- Photoperiod (hrs dark / hrs light): 12/12 hour, light/dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- Four New Zealand White rabbits of each sex were exposed for 24 h with a bandage containing doses of 2.0 or 3.0 g/kg body weight of white spirit (Stoddard solvent) (14.5% aromatics). The exposed area, which measured about 10% of the body surface, was shaved before exposure and the skin of two animals in each dose group was abraded.
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg and 3000 mg/kg
- No. of animals per sex per dose:
- 4 male/female rabbits
- Control animals:
- yes
- Details on study design:
- Four New Zealand White rabbits of each sex were exposed for 24 h with a bandage containing doses of 2.0 or 3.0 g/kg body weight of white spirit (Stoddard solvent) (14.5% aromatics). The exposed area, which measured about 10% of the body surface, was shaved before exposure and the skin of two animals in each dose group was abraded.
All animals exhibited loss of appetite and hypoactivity on the first day after exposure. At the lowest dose level thickening and redness of the skin developed. One low-dose female with skin abrasion died three days after exposure
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no signs of systemic or organ toxicity were noted.
- Mortality:
- All ten animals survived to termination of the study.
- Clinical signs:
- other: Dermal irritation that lasted till termination of the study.
- Gross pathology:
- No visible lesions, with the exception of the dermal effects.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- The LD50 for Stoddard solvent is >3000 mg/kg. Based on these findings, Stoddard solvent does not warrant classification as an acute dermal toxicant under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
- Executive summary:
Four New Zealand White rabbits of each sex were exposed for 24 h with a bandage containing doses of 2.0 or 3.0 g/kg body weight of white spirit (Stoddard solvent) (14.5% aromatics). The exposed area, which measured about 10% of the body surface, was shaved before exposure and the skin of two animals in each dose group was abraded.
All animals exhibited loss of appetite and hypoactivity on the first day after exposure. At the lowest dose level thickening and redness of the skin developed. One low-dose female with skin abrasion died three days after exposure
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