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EC number: 619-383-6 | CAS number: 98967-40-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 28 June 1988 to 5 August 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-2 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- EC Number:
- 619-383-6
- Cas Number:
- 98967-40-9
- Molecular formula:
- C12H9F2N5O2S
- IUPAC Name:
- N-(2,6-difluorophenyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- Reference substance name:
- N-(2',6'-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- IUPAC Name:
- N-(2',6'-difluorophenyl)-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine-2-sulfonamide
- Details on test material:
- - Physical state: white powder
- Analytical purity: 99.6%
- Lot/batch No.: AGR 240043
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hazelton Dutchland, Inc, Denver, PA
- Weight at study initiation: 2.8 to 3.1
- Housing: Individually
- Diet (e.g. ad libitum): Purina Certified Rabbit Chow #5322
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: two weeks
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunk
- Type of wrap if used: Gauze dressing and non-irritating tape, and plastic wrap, with five mL of distilled water injected under the cuff to ensure sufficient skin contact; plastic warp was covered by a cloth bandage taped securely to the fur.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Washed with mild soap and water and dried with soft disposable towel
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2000 mg of test material per kg body weight - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg test material per kg body weight
- No. of animals per sex per dose:
- 5 animals total
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: weighed on day of treatment and on test days 2, 8 and 15
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Means and standard deviations were calculated for body weights, data were evaluated for statistical outliers.
Results and discussion
- Preliminary study:
- no information
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- no morality
- Clinical signs:
- other: No effect of dermal test site or any other organ at necropsy.
- Gross pathology:
- No effect of dermal test site or any other organ at necropsy.
- Other findings:
- No information
Applicant's summary and conclusion
- Interpretation of results:
- other: acute dermal toxicity classified as low
- Remarks:
- Criteria used for interpretation of results: US EPA pesticides
- Conclusions:
- No LD50 could be determined at or below 2000 mg/kg bw. Acute dermal toxicity of XRD-498 was categorized as low.
- Executive summary:
XRD-498 was evaluated for acute dermal toxicity in New Zealand White rabbits. Five rabbits per sex received a single dermal 24 -hour exposure to 2000 mg/kg of XRD-498. Parameters examined during the two-week observation period included body weights and in-life clinical observations. All animals were examined for gross pathologic changes. All animals survived the 2000 mg/kg limit test established by the guideline and therefore no other dose level was tested. All animals were in apparent good health throughout the study and gained weight by study termination. There was no effect atthe dermal test site or any other organ at necropsy. It was therefore concluded that under the conditions of this study, the acute dermal LD50 of XRD-498 was greater than 2000 mg/kg. Based on these results, the acute dermal toxicity of XRD-498 was categorized as low.
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