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EC number: 216-381-3 | CAS number: 1570-64-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Taken from EU Risk Assessment Report - Reviewed by the Danish Environmental Protection Agency. Guideline Study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-chloro-o-cresol
- EC Number:
- 216-381-3
- EC Name:
- 4-chloro-o-cresol
- Cas Number:
- 1570-64-5
- Molecular formula:
- C7H7ClO
- IUPAC Name:
- 4-chloro-2-methylphenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: caged
- Diet (e.g. ad libitum): conventional laboratory diet.
- Water (e.g. ad libitum): Ad libitium
- Acclimation period:At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C +/- 3°C
- Humidity (%): 30-70%
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12hour light / 12 hours dark
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: 50% alcohol (alcohol not specified)
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- ca. 4 h
- Concentrations:
- Control: 0 mg/m3
Test concentrations : 5.79, 8.33, 9.11 and 10 % 4-chloro-o-cresol as an aerosol in 50% alcohol.
This equates to a concentration in air of 0.579 -1.08 mg/L - No. of animals per sex per dose:
- 5 male and 5 female rats per dose.
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 0.9 mg/L air (nominal)
- Exp. duration:
- 4 h
- Remarks on result:
- other: The range for mortalities was 0.83 - 1.08 mg/L (nominal)
- Mortality:
- All deaths occuring in the study occurred during exposure or within the first hour after exposure.
The details are summarised in Table 1 included in the remarks section below. - Clinical signs:
- other: Symptoms observed during and after exposure were respiration difficulties, depressions, ruffled fur and bleeding from the nose. These symptoms were dose related. Petechiae of the lungs were also observed.
- Gross pathology:
- Examination of the animals that died within the first hour of dosing showed bleeding of the lungs and the small intestine was found to contain a thin yellowish mucus.
Any other information on results incl. tables
Table 1. Summary of Mortalities.
Dose level, mg/L | Mortality/No in group |
0 (Control) | 0/10 |
0.579 | 0/10 |
0.833 | 2/10 |
0.911 | 4/10 |
1.08 | 7/10 |
Applicant's summary and conclusion
- Interpretation of results:
- other: toxic
- Remarks:
- Criteria used for interpretation of results: other: Approved Classification and Labelling Guide (Sixth Edition), Chemicals (Hazard Information and Packaging for Supply) Regulations 2009 (CHIP 4)
- Conclusions:
- Based on the results from this study 4-chloro-o-cresol is considered to be toxic by inhalation.
- Executive summary:
A guideline study was performed on groups of 10 rats (5 male/5 female). The animals were exposed to the equivalent of 0, 0.579, 0.833, 0.911 and 1.08 mg/L of 4 -chloro-o-cresol administered as an aerosol in 50% alcohol.
All deaths during the study occurred during exposure or within the first hour after exposure.
The mortalities are summarised in the table below.
Dose level, mg/L Mortality/No in group 0 (Control) 0/10 0.579 0/10 0.833 2/10 0.911 4/10 1.08 7/10 Symptoms observed during and after exposure were respiration difficulties, depressions, ruffled fur and bleeding from the nose. These symptoms were dose related. Petechiae of the lungs were also observed.
Examination of the animals that died within the first hour of dosing showed bleeding of the lungs and the small intestine was found to contain a thin yellowish mucus.
The LD50 was determined to be 0.9 mg/L air.
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